Hans algorithm
Germinal center
CD10+
or
CD10- BCL6+ MUM1-
PNH screening
sucrose test
PNH confirmation
flow cy (CD55)
Hb Barts
four gamma-globin chains
function of ADAMTS13
cuts large vWF strands to prevent plt clumping
B-ALL translocation assoc with good prognosis >90% cure rate
t (12;21)/ ETV6-RUNX1
NGS required tumor content and tumor cells
> 10%
1000 tumor cells
LCH
solitary bone
multiple bone
multiple organ
eos granuloma
Hand-Schuller-Christian - exopthalmos, DI
Letterer-Siwe - fatal, skin rash
lipid-storing histiocytosis of non-langerhans type
Erdheim-Chester disease
TS (transferrin saturation) in IDA
Ratio of serum iron to IBC (iron binding capacity)
Normal: 1:3
IDA: 1:5 or lower