Ceftriaxone

Question 1

Pharmacology and presentation of Ceftriaxone?

Answer 1

1g powder ampoule

Ceftriaxone is a broad-spectrum cephalosporin antibiotic. That inhibits production of the bacteria cell wall, causing bacteria death

Question 2

Indicators of Ceftriaxone?

Answer 2

• Suspected meningococcal septicaemia
• Severe sepsis on consult

Question 3

Contraindications of Ceftriaxone?

Answer 3

• Hypersensitivity to cephalosporins.

Question 4

Cautions of Ceftriaxone?

Answer 4

• Allergy to penicillin

Question 5

Side Effects of Ceftriaxone?

Answer 5

• Rash
• Nausea & Vomiting

Question 6

Dosing Regimes of Ceftriaxone?

Answer 6

Adult
- 2 g IV or IM
- Nil repeats

Paediatrics
- 50mg/kg (max 2g) IV or IM
- Nil repeats

Ceftriaxone IV must be made up to 10ml using normal saline and administrered over 2 minutes.

Ceftriaxone IM must be made up to 4ml using 1% Lignocaine and administered in the lateral upper thigh.

Question 7

Onset and duration of Ceftriaxone?

Answer 7

Onset:
- 30-60 minutes

Duration
- 24 hours