Ondansetron

Question 1

Pharmacology and presentation of Ondansetron?

Answer 1

4mg/2ml Ampoule

Ondansetron is a serotonin 5-HT3 receptor antagonist used primarily as an antiemetic. Ondansetron reduces the activity of the vagus nerve, which activates the vomiting centre in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone.

Question 2

Indicators of Ondansetron?

Answer 2

• Nausea and vomiting associated with: cardiac chest pain, cytotoxic drugs/radiotherapy, gastroenteritis, previously diagnosed migraine
• Prophylaxis use in: motion sickness, aeromedical evacuation, spinal, eye trauma

Question 3

Contraindications of Ondansetron?

Answer 3

• Hypersensitivity
• Age <2 years

Question 4

Cautions of Ondansetron?

Answer 4

• Impaired hepatic function
• Elderly
• Pregnancy
• Lactation

Question 5

Side Effects of Ondansetron?

Answer 5

• Headache
• Skin flushing
• Extrapyramidal reactions
• Arrhythmia

Question 6

Dosing Regimes of Ondansetron?

Answer 6

.

Question 7

Onset and duration of Ondansetron?

Answer 7

• Onset = 2 minutes
• Duration = 2 hours