Ibuprofen

Question 1

Pharmacology and presentation of Ibuprofen?

Answer 1

200mg Tablet
100mg/5ml liquid

Ibuprofen is a NSAID, predominantly used as an analgesic. Inhibits prostaglandin synthetase, reducing prostaglandin production and causing a reduction in inflammation, pain and fever.

Question 2

Indicators of Ibuprofen?

Answer 2

• Mild to moderate pain secondary to inflammation or soft tissue injury.

Question 3

Contraindications of Ibuprofen?

Answer 3

• Hypersensitivity
• Heart failure/CVD
• Pregnancy - 3rd trimester
• Pt taking anticoagulants
• Previous renal disease
• Severe renal impairment
• Current bleed, GI bleed or peptic ulcer
• Children <3 months

Question 4

Cautions of Ibuprofen?

Answer 4

• Asthma (increased bronchospasm)
• Previous hx of GI bleeding or peptic ulcers
• Dehydration, hypovolaemia, diuretic treatment
• Elderly
• Varicella Zoster (Chicken pox)

Question 5

Side Effects of Ibuprofen?

(2x head 2x stomach)

Answer 5

• Nausea
• Dyspepsia
• Gastrointestinal bleeding
• Dizziness.

Question 6

Dosing Regimes of Ibuprofen?

Answer 6

Adults
- 400mg PO, single dose only

Paeds
- 10mg/kg PO, single does only

Question 7

Onset and duration of Ibuprofen?

Answer 7

• Onset = 15 minutes
• Duration = 4–6 hours