Morphine

Question 1

Pharmacology and presentation of Morphine?

Answer 1

10mg:1ml

Morphine is an opiate analgesic that acts on the central nervous
system by binding with opioid receptors, leading to CNS depression, resp depression, cough reflex depression, stimulation (mood, euphoria/dysphoria, vomiting) and potential for dependence. It also decreases the rate of AV conduction and can
precipitate vasodilatation

Question 2

Indicators of Morphine?

Answer 2

• Pain relief
• Sedation to maintain intubation

Question 3

Contraindications of Morphine?

Answer 3

• Hypersensitivity
• Labour

Question 4

Cautions of Morphine?

(HEARMARK)

Answer 4

• Elderly
• Hypotension
• Respiratory depression
• Asthma
• Resp tract burns
• Known addiction to narcotics
• Acute alcoholism
• Monoamine Oxidase Inhibitors

Question 5

Side Effects of Morphine?

(5x Head, 2x Heart, 1x Lung)

Answer 5

• Bradycardia
• Hypotension
• Drowsiness
• Respiratory depression
• Euphoria
• Nausea and/or Vomiting
• Pinpoint pupils
• Addiction

Question 6

Dosing Regimes of Morphine?

Answer 6

IM/SC
- Adults = 0.1mg/kg IM/SC to a max of 10mg, repeated once after 20 mins
- Paeds = 0.1mg/kg IM to a max of 5mg in a single dose, consult for further doses if required

IV/IO
- Adults = 0.05mg/kg IV/IO to a max of 5mg per dose (1mg = 20kg), repeating 5 minutely to a max of 20mg

Question 7

Onset and duration of Morphine?

Answer 7

• Onset = 2-5mins IV or 10-30mins IM
• Duration = 1-2hrs