l-E. The superior oblique muscle depresses, abducts, and intorts the eye. Paralysis of this mus-
cle results in extorsion and weakness of downward gaze. Head tilting compensates for extorsion.
2-E. The hypoglossal nerve (CN XII) passes through the hypoglossal canal, not through the
jugular foramen. It innervates the intrinsic and extrinsic muscles of the tongue (genioglossus,
styloglossus, and hyoglossus).
3. The cavernous sinus contains all of the fol- lowing structures EXCEPT the (A) ophthalmic nerve (B) mandibular nerve (C) abducent and trochlear nerves (D) postganglionic sympathetic fibers (E) preganglionic parasympathetic fibers
3-B. The mandibular nerve (CN V-3) does not pass through the cavernous sinus; it exits the skull
via the foramen ovale.
4. The superior orbital fissure contains all of the following structures EXCEPT the (A) ophthalmic veins (B) ophthalmic nerve (C) trochlear nerve (D) abducent nerve (E) optic nerve
4-E. The optic nerve (CN II) enters the skull via the optic canal. The optic canal also contains
the ophthalmic artery.
the ophthalmic artery.
5-C. Transection of the oculomotor nerve (CN III) does not interrupt the afferent limb of the
pupillary reflex, which is bilateral. Light shone into the left eye results in constriction of the con-
tralateral pupil, the consensual reaction.
6-D. The right trochlear nucleus of CN IV projects to the left superior oblique muscle. Diplopia
occurs when an image falls on disparate parts of the retina. The pupillary light reflex is medi-
ated by the parasympathetic fibers of the oculomotor nerve
7-E. The vestibulocochlear nerve (CN VIII) is classified as a special somatic afferent (SSA)
nerve, as is the optic nerve (CN II).
8-D. The geniculate ganglion contains all of the first-order sensory neurons of the facial nerve
(CN VII) [general somatic afferent (GSA) and special visceral afferent (SVA)]. It is found within
the temporal bone and gives rise to the greater petrosal nerve. Sensory neurons in the genicu-
late ganglion innervate taste buds from the anterior two-thirds of the tongue. Taste fibers from
the posterior third of the tongue belong to the glossopharyngeal nerve (CN IX). Pseudounipolar
ganglion cells of the geniculate ganglion innervate part of the outer ear.
9-D. The olfactory nerve (CN I), a special visceral afferent (SVA) nerve, consists of the un-
myelinated axons of bipolar neurons found in the olfactory epithelium of the upper nasal cavity.
There are 25 million neurosensory cells on each side. These axons synapse with mitral cells in
the olfactory bulb, a rhinencephalic structure of the forebrain. Mitral cells project directly via the
olfactory tract to the primary olfactory cortex of the uncus.
10-A. The optic nerve (CN II) enters the skull via the optic canal of the sphenoid bone (the oph-
thalmic artery is also found in the optic canal). Efferent retinal fibers are the afferent limb of the
pupillary light reflex. The efferent limb is the oculomotor nerve (CN III). The optic nerve is in-
vested with meninges and lies in the subarachnoid space. The optic nerve is a tract of the cen-
tral nervous system (CNS) and not a peripheral nerve. There is no regeneration after transec-
tion. The axons of the optic nerve are myelinated by oligodendrocytes; peripheral nerve axons
are myelinated by Schwann cells.
11-D. The oculomotor nucleus is found in the rostral midbrain at the level of the superior col-
liculus. Ptosis results after transection of the fibers to the levator palpebrae muscle. The oculo-
motor nerve (CN III) traverses the wall of the cavernous sinus with CN IV, CN VI, CN V-l, and
CN V-2. The oculomotor nerve has a general visceral efferent (GVE) parasympathetic component,
which arises from the Edinger-Westphal nucleus. CN III exits the cranium via the superior or-
bital fissure.
12-C. The accessory (spinal) nerve (CN XI) exits the skull via the jugular foramen (with CN IX
and CN X). The spinal part of the spinal accessory nerve enters the skull via the foramen mag-
num. CN XI contains SVE fibers from the nucleus ambiguus that innervate intrinsic muscles of
the larynx; CN XI contains special visceral efferent (SVE) fibers from the cervical spinal cord that 12-C. The accessory (spinal) nerve (CN XI) exits the skull via the jugular foramen (with CN IX
and CN X). The spinal part of the spinal accessory nerve enters the skull via the foramen mag-
num. CN XI contains SVE fibers from the nucleus ambiguus that innervate intrinsic muscles of
the larynx; CN XI contains special visceral efferent (SVE) fibers from the cervical spinal cord that innervate two muscles of branchiomeric origin—the trapezius and the sternocleidomastoid. The
dorsal motor nucleus is the general visceral efferent (GVE) nucleus of the vagal nerve (CN X).
13-E. The facial nerve (CN VII) provides the preganglionic parasympathetic innervation for the
lacrimal, sublingual, and submandibular glands and innervates the stapedius muscle of the tym-
panic cavity and the posterior belly of the digastric muscle. The otic ganglion receives pregan-
glionic parasympathetic input from the glossopharyngeal nerve (CN IX) and projects postgan-
glionic parasympathetic fibers to the parotid gland.
14-E. The trigeminal nerve (CN V) [general somatic afferent (GSA) and special visceral effer-
ent (SVE)] innervates the tensor tympani muscle, the anterior belly of the digastric muscle, and
the supratentorial dura. The skin over the angle of the jaw and the scalp of the back of the head
are innervated by the second and third cervical nerves.
15-B. Transection of the glossopharyngeal nerve (CN IX) results in degeneration of neurons in
the rostral part of the nucleus ambiguus and in the inferior salivatory nucleus, loss of the gag re-
flex, loss of sensation from the tonsillar bed, loss of taste and pain sensation from the posterior
third of the tongue, and loss of the carotid sinus reflex. The superior salivatory nucleus is a gen-
eral visceral efferent (GVE) nucleus of CN VII.
(A) Glossopharyngeal nerve (B) Accessory nerve (C) Trigeminal nerve (D) Facial nerve (E) Vagal nerve
16-A. The glossopharyngeal nerve (CN IX) innervates the parotid gland via the tympanic and
lesser petrosal nerves, the otic ganglion, and the auriculotemporal nerve.
17. Is the efferent limb of the corneal reflex (A) Glossopharyngeal nerve (B) Accessory nerve (C) Trigeminal nerve (D) Facial nerve (E) Vagal nerve
17-D. The facial nerve (CN VII) provides the efferent limb of the corneal reflex (orbicularis oculi
muscle).
18. Is the efferent limb of the gag reflex (A) Glossopharyngeal nerve (B) Accessory nerve (C) Trigeminal nerve (D) Facial nerve (E) Vagal nerve
18-E. The vagal nerve (CN X) provides the efferent limb of the gag reflex (muscles of the soft
palate). The glossopharyngeal nerve provides the afferent limb of the gag reflex.
19. Innervates the infratentorial dura (A) Glossopharyngeal nerve (B) Accessory nerve (C) Trigeminal nerve (D) Facial nerve (E) Vagal nerve
19-E. The vagal nerve (CN X) innervates, via the recurrent meningeal ramus, the infratentor- ial dura (the dura of the posterior cranial fossa).
20. Is a pure motor nerve (A) Glossopharyngeal nerve (B) Accessory nerve (C) Trigeminal nerve (D) Facial nerve (E) Vagal nerve
20-B. The accessory nerve (CN XI) is a pure special visceral efferent (SVE) motor nerve. The
cranial division innervates, via the recurrent laryngeal nerve, the intrinsic muscles of the lar-
ynx; the spinal division innervates, via motor branches, the sternocleidomastoid muscle and up-
per parts of the trapezius muscle.
21. A branch of the maxillary artery (A) Foramen jugular (B) Innominate canal (C) Foramen magnum (D) Foramen ovale (E) Foramen rotundum (F) Foramen spinosum (G) Foramen stylomastoidum (H) Superior orbital fissure
21-F. The middle meningeal artery, a branch of the maxillary artery, traverses the foramen spin-
osum.
(A) Foramen jugular (B) Innominate canal (C) Foramen magnum (D) Foramen ovale (E) Foramen rotundum (F) Foramen spinosum (G) Foramen stylomastoidum (H) Superior orbital fissure
22-G. The facial nerve (CN VII) exits the base of the skull via the stylomastoid foramen; CN VII
innervates the muscles of facial expression, including the buccinator muscle.
23. The nerve that innervates the skin of the upper lip (A) Foramen jugular (B) Innominate canal (C) Foramen magnum (D) Foramen ovale (E) Foramen rotundum (F) Foramen spinosum (G) Foramen stylomastoidum (H) Superior orbital fissure
23-E. The maxillary nerve (CN V-2) exits the skull via the foramen rotundum.
24. Cranial nerves IX, X, and XI (A) Foramen jugular (B) Innominate canal (C) Foramen magnum (D) Foramen ovale (E) Foramen rotundum (F) Foramen spinosum (G) Foramen stylomastoidum (H) Superior orbital fissure
24-A. Cranial nerves IX, X, and XI exit the posterior cranial fossa via the jugular foramen.