Chapter 4: Pharmacogenetics

Question 1

_______ is the study of how a patient’s genomes affect drug response

Answer 1

pharmacogenetics

Question 2

Who are the people that benefit the most from pharmacogenetics?

Answer 2

those taking multiple drugs, those not responding to drug therapy those with adverse drug reactions, and those who are taking black box warning drugs.

Question 3

what percentage of people do not react the way that they should with statins?

Answer 3

70%

Question 4

______ metabolizers metabolize at the normal rate

Answer 4

Extensive

Question 5

_____ metabolizers metabolize very slowly

Answer 5

intermediate/poor

Question 6

_______ metabolizers metabolize drugs too quickly

Answer 6

ultra

Question 7

______ causes myelosuppression white blood cells to drop too low red blood cells to drop too low platelets to drop too low

Answer 7

Mercatopurine

Question 8

why shouldn’t mercatopurine be given to slow metabolizers?

Answer 8

their bone marrow will be wiped out

Question 9

____ can we used when treating colon cancer people with colon cancer that have variations have side effects that include severe diarrhea and neutropenia

Answer 9

Irinotecan

Question 10

______ is frequently used for HIV and hyper sensitivity

Answer 10

Abacavis

Question 11

what is the antidote for warfarin?

Answer 11

vitamin K

Question 12

______ is a blood thinner. An anticoagulant can be used with those that have deep vein thrombosis, but has a very low therapeutic range and only 9 to 10% prescribed tend to have a lot of bleeding.

Answer 12

Warfarin

Question 13

_______ is a drug that needs to be metabolized to be active

Answer 13

Pro drug

Question 14

Give 3 examples of prodrugs

Answer 14

Clopidogerol
Codeine
Tramadol

Question 15

many people given _____ i’m missing the enzyme to be converted into active drugs

Answer 15

clopidogerol

Question 16

where are many mental health drugs metabolized?

Answer 16

In cytochrome P450 group

Question 17

_______ is an anticonvulsant an anti-seizure medication but some people have a variant that makes them develop Stephen Johnson syndrome, which manifest as a total body rash that could progress into a third-degree burn

Answer 17

Carbamazepine

Question 18

What does GINA stand for?

Answer 18

Genetic non discrimination act