A patient will be sent home with a metered-dose inhaler, and the nurse is providing teaching.
Which is a correctly written expected outcome for this process?
a. The nurse will demonstrate the correct use of a metered-dose inhaler to the patient.
b. The nurse will teach the patient how to administer medication with a metered-dose
inhaler.
c. The patient will know how to self-administer the medication using the metered-
dose inhaler.
d. The patient will independently administer the medication using the metered-dose
inhaler at the end of the session.
d. The patient will independently administer the medication using the metered-dose
inhaler at the end of the session.
c. suggest putting the inhaler with the child’s toothbrush to use before brushing teeth.
a. autonomy.
In a 5-year clinical trial investigating a new cancer treatment, researchers note overwhelming
improvement in almost all of the subjects in the treatment group during the second year of the
trial. It is decided to stop the trial early and report the findings due to the overwhelmingly
beneficial effects. This decision was made based on which ethical principle?
a. Beneficence
b. Justice
c. Respect for persons
d. Veracity
b. Justice
d. receive the experimental treatment being evaluated.
During a clinical drug trial for a new medication, researchers note a previously unknown serious
adverse effect occurring in more than 50% of subjects. The study is discontinued. Which ethical
principle is being exercised?
a. Beneficence
b. Justice
c. Respect for persons
d. Veracity
a. Beneficence
The nurse is obtaining signatures on consent forms for participation in a clinical drug trial. One
patient says, “I’m not sure I want to do this, but I need the cash.” The nurse will take which
action?
a. Ask the patient to clarify concerns.
b. Reinforce that cash is given to all subjects equally.
c. Report this statement to the lead investigator.
d. Review the elements of the study and obtain consent.
c. Report this statement to the lead investigator.
Which of the following best describes preclinical in vivo testing?
a. A comparison of experimental and control data in animals.
b. A study conducted in a test tube in a laboratory.
c. A study that determines the effects of the experimental product in human
participants.
d. A study to assess the seriousness of the disease to be treated.
a. A comparison of experimental and control data in animals.
The nurse is assisting with data collection in a study of drug effects in a small group of healthy
subjects. The nurse assists with blood and urine collection to determine serum drug levels and
the presence of metabolites in urine. Which phase of drug development does this best represent?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
a. Phase I
The nurse is enrolling subjects for a clinical drug trial in which subjects will be randomly
assigned to either a treatment or a placebo group. The pills in both groups will be in identical
packaging with identical appearance. The group that receives the intervention is the
a. control group.
b. experimental group.
c. dependent group.
d. independent group.
b. experimental group.
Respect for persons is a core ethical principle of human subjects research. Which of the
following best describes this principle?
a. Duty to protect research subjects from harm.
b. Fair selection of research subjects.
c. Right to self-determination.
d. Patients are independent and capable of making decisions in their own best interests.
d. Patients are independent and capable of making decisions in their own best interests.
Before marketing a new drug that has been approved for use based on clinical effectiveness and
safety, the manufacturer wishes to study the potential new uses for the drug. This is an example
of which phase of study?
a. Phase I
b. Phase II
c. Phase III
d. Phase IV
d. Phase IV
c. Liquid suspension
c. digestive enzymes in the GI tract break down the drug and prevent absorption.
b. requires active transport for absorption.
The nurse is preparing an injectable drug and wants to administer it via the route that will allow
for the most rapid absorption possible. How will the nurse give this medication (if possible)?
a. IM into the deltoid muscle
b. IM into the gluteal muscle
c. SQ into abdominal tissue
d. SQ into the upper arm
a. IM into the deltoid muscle
b. “The first-pass effect means the drug is absorbed from the GI tract into the portal vein where it is transported to the liver and metabolized.”
The nurse prepares to change a patient’s medication from an IV to an oral form and notes that the
oral form is ordered in a higher dose. The nurse understands that this is due to differences in
a. bioavailability.
b. pinocytosis.
c. protein binding.
d. tachyphylaxis.
a. bioavailability.
The nurse is preparing to administer a drug and learns that it is 90% protein bound. The patient’s
serum albumin level is low. The nurse will observe the patient for
a. decreased drug absorption.
b. decreased drug interactions.
c. decreased drug toxicity.
d. increased drug effects.
d. increased drug effects.
The nurse is administering two drugs to a patient and learns that both drugs are highly protein-
bound. The nurse may expect
a. decreased bioavailability of both drugs.
b. decreased drug effects.
c. decreased drug interactions.
d. increased risk of adverse effects.
d. increased risk of adverse effects.
A patient has been taking a drug that is 75% protein bound. The provider adds a new medication
that is 90% protein bound. The nurse will expect a potential
a. decreased drug effects of the first drug.
b. decreased therapeutic range of the first drug.
c. increased drug effects of the first drug.
d. increased therapeutic range of the first drug.
c. increased drug effects of the first drug.
The nurse is caring for a patient who has ingested a large dose of aspirin several hours prior. It is
determined that the patient has overdosed on aspirin. The provider orders sodium bicarbonate to
be given. The nurse understands that this drug is given for which purpose?
a. To counter the toxic effects of the aspirin
b. To decrease the half-life of the aspirin
c. To increase the excretion of the aspirin
d. To neutralize the acid of the aspirin
c. To increase the excretion of the aspirin
A patient has been taking a drug that is 75% protein bound. The provider adds a new medication
that is 90% protein bound. The nurse will expect a potential
a. decreased drug effects of the first drug.
b. decreased therapeutic range of the first drug.
c. increased drug effects of the first drug.
d. increased therapeutic range of the first drug.
c. increased drug effects of the first drug.
The nurse administers albuterol to a patient who has asthma. The albuterol acts by stimulating
beta2-adrenergic receptors to cause bronchodilation. The nurse understands that albuterol is a
beta-adrenergic
a. agonist.
b. antagonist.
c. inhibitor.
d. depressant.
a. agonist.