A 3-year-old child is seen by his mother to suddenly turn blue around the lips after an episode of crying. This has happened many times previously and the child quickly adopts the squatting position to relieve his symptoms. On previous examinations, the child has been seen to have multiple cardiac problems, including a boot-shaped heart on chest x-ray.
Based on the most likely diagnosis, what is the most likely diagnosis and what occurs in this?
Tetralogy of Fallot
failed migration of neural crest cells contributes to the anterior and superior displacement of the infundibular septum - septum is malpositioned
Give 4 examples of cyanotic heart defects.
cyanotic:
- TOF
- tricuspid atresia
- transposition of great arteries
- hypoplastic left heart
Give 4 examples of acyanotic heart defect.
acyanotic:
- atrial septal defect
- patent foramen ovale
- ventricular septal defect
- coarctation of aorta
A baby is premature, born at 30 weeks, putting her at higher risk for delayed ductus venosus closure.
Which structures does the ductus venosus act as a communication between in the fetus?
umbilical vein to IVC
A 2-week-old female is referred to the paediatrician due to poor feeding and poor weight gain. On cardiac auscultation, a continuous ‘machine-like’ murmur is heard. An echocardiogram reveals a patent ductus arteriosus (PDA).
If this structure had closed at birth, what would the remnant be called?
ligamentum arteriosum
(small fibrous band connecting pulmonary trunk to the aortic arch)
A 20-year-old man has been found to have an abnormal electrical connection in his heart causing him to have frequent palpitations, dizzy spells, and shortness of breath. Delta waves are also noted on the ECG. Ablation of the coronary sinus is considered as a treatment for this condition.
What is the condition?
The target for this surgery is derived from which embryological structure?
condition: Wolff-Parkinson-White syndrome (delta waves on ECG are giveaway)
in WPW there’s an accessory conduction pathway that bypasses the AV node, causing pre-excitation of the ventricles
they’re talking about ablation of the coronary sinus which develops from the LEFT HORN of the SINUS VENOSUS
What cardiac structures close in a newborn within a few hours of birth? Explain.
foramen ovale
- septum primum and septum secundum are forced together which closes foramen ovale
ductus arteriosus
- vessel connecting the pulmonary artery to the aorta, letting blood bypass the non-functional fetal lungs
- closes and becomes ligamentum arteriosum
- if stays open = PDA - blood flows from aorta to pulmonary artery
In foetal circulation, what is the role of the following:
Fill in the gaps:
Developing __1__ receives __2__ blood from the mother via __3__ and __4__ vein.
Label the image.
What are the 3 foetal circulatory shunts and what do they do?
Which foetal shunt allows blood to move from the right atrium to the left atrium?
foramen ovale
What foetal shunt connects the umbilical vein to the IVC, carrying mostly highly oxygenated blood away from the liver?
ductus venosus
What foetal shunt connects the aorta and the pulmonary artery shunting blood away from the lungs?
ductus arteriosus
What does the truncus arteriosus give rise to?
ascending aorta and pulmonary trunk
A 65-year-old male presents to the emergency department with sudden onset of severe chest pain. He describes the pain as ‘ripping through his body’. He is quickly diagnosed with a Stanford Type A aortic dissection and taken off for surgical repair.
Which of the following embryonic structures gives rise to the area in which the dissection occurred?
truncus arteriosus
(stanford type A aortic dissection takes place in the ascending aorta)
A mother brings her baby to the Emergency Department after she notices a pale yellow fluid leaking from its umbilicus. Her doctor explains that this is because of the failed closure of what used to be part of the embryological umbilical ligament.
What is the name of this remnant?
urachus
(remnant of the allantois, which is the remnant of the embryological umbilical ligament)
A 35-year-old man presents to his general practitioner (GP) complaining of a fever and malaise. On questioning the GP finds out that he is has been using IV drugs for the past few years and after careful examination suspects infective endocarditis.
The structure most likely affected in this patient is derived from what embryological structures?
endocardial cushion
infective endocarditis in patients positive for IVDU most commonly affects tricuspid valve - all valves in the heart are derived from endocardial cushion
A 4-week old boy is brought to the general practitioner (GP) after his mother has seen daily yellowish drainage coming from his umbilicus. The infant had an uncomplicated delivery and is otherwise well.
This problem is most likely caused by abnormal development of which embryological structures?
allantois
(persistent allantois can lead to a patent urachus - presents are urinary drainage from the umbilicus)
What does the right atrium develop from?
primitive atrium and sinus venosus
What is an unfused fossa ovalis called?
patent foramen ovale