GI 6

Question 1

Malabsorptive disorders are a result of

Answer 1

myriad of diseases that have malabsorption of nutrients as a consequence

Question 2

malabsorptive disorders: typically affect this

Answer 2

small intestine (where most nutrients are absorbed)

Question 3

malabsorptive disorders: conditions

Answer 3

• celiac disease
• infections
• short gut syndrome 2˚ to surgery
• structural defects

Question 4

What is the most common malabsorptive disorder?

Answer 4

celiac disease

Question 5

What is celiac?

Answer 5

• immune-mediated disorder

- triggered by exposure to gluten

Question 6

prevalence of celiac

Answer 6

~ 1% of population

Question 7

celiac risk factors

Answer 7

• other autoimmune disorders
• IgA deficiency
• genetic syndromes
• family hx
• DM I
• thyroiditis

Question 8

celiac disease pathogenesis: What happens when the small intestine is exposed to gluten?

Answer 8

• immune response triggered
• T cells aggregate into small intestine mucosa
• inflammatory response leads to destruction of intestinal cells

Question 9

celiac disease is linked to a higher risk of:

Answer 9

cancer

Question 10

celiac dz: s/s

Answer 10

• broad range (makes dx difficult)
• severe diarrhea, bloating, indigestion
• WL
• abd cramping
• nutrient deficiency
• long-term complications

Question 11

celiac dz: nutrient deficiency

Answer 11

• folate
• iron
• fat-soluble vitamins
• Vitamin B12

Question 12

celiac dz: long-term complications

Answer 12

• OP
• infertility
• coagulation abnormalities
• anemia
• neuro probs

Question 13

skin manifestations of celiac

Answer 13

dermatitis herpetiformis