SAAG> 11
Portal HTN
SAAG <11
Hypoalbuminaemia
Malignancy
Bowel obstruction
gastric carcinoma
pernicious anaemia can be a cause
SBP
Paracetesis - neutrophil count >250
E coli most common
IV ceftoxamine
ABX prophylaxis - had episode of SBP - oral copra
C diff treatment
1.Oral vanc (10 days)
2. Oral fidoxamicin
3. Oral vanc +/- IV metronidazole
Recurrent C diff
Within 12 weeks of symptom onset - oral fidoxanicin
After 12 weeks of symptom onset - oral vanc OR fidoxanicin
Life treatening C diff
Oral vanc and IV metronidazole
IBS treatment
Pian cramping etc = mebeverine
Laxatives and loperamide
CROHNS FEATURES
No blood or mucus
Entire GI tract
Skip lesions
Terminal ileum, transmural
Smoking is a RISK FACTOR
Deep ulcers
Goblet cells and granulomas
Kantors string adn rose thorn ulcers
CROHNS TREATMENT
Inducing remission
- glucocorticoids
mesalazine
azathriopine
metronidazole ( also for fistula)
Maintaining remission
- azathioprine or mercaptopurine
methotrexate
UC features
Continuous inflammation
Limited to the colon and rectum
Only superficial mucosa
Smoking protective
Excrete blood and mucus
PSC
No inflammation beyond submucosa
Crypt abscesses
Pseudopolyps
Barium enema shows loss of haustration
DRAINPIPE COLON
GET BLOOD AND PIAN IN LEFT LOWER QUADRANT
UC treatment
Inducing remission
Topical aminosalicyate
Rectal aminocysalicate
Topical/oral corticosteroid
Extensive - Topical aminosalicyate and oral
Severe = IV steroids or IV ciclosporin
Maintaining
- Topical rectal aminosalicyate
left sided/ extensive - oral aminosalicyate
Severe relapse or >2 exacerbations in last year = oral azaioopthrine/ oral mercapnione
What to check for azaithoprine
TPMT
Alchasia
Solids and liquids
Heartburn, regurgitation
Oesphageal manometry - excesive LOS tone
Barium swallow = birds beak
Pneumatic dilation, Heller cadiomyotomy surgery if recurrent
Pharyngeal pouch
Dysphagia, regurgitation, aspiration, neck swelling, halitosis
barium swallow and dynamic video fluoroscopy
Surgery
HCC
High ALT/ALT
Liver cirrhosis
Surgical resection
SORAFENIB for metastatic
Gilbert
Autosomal recessive
Defective bilirubin coagulation
Unconjugated bilirubinaemia
Jaundice during illness
Wilsons
Autosomal recessive, copper deposition in tissues
Hepatitis, speech, behavioural and psych problems, Kayser fleshier rings, renal tubular acidosis, haemolysis
Slit lamp, increased copper urinary 24hr excretion
—> penacillaemine ( chelates copper)
Haemorrhoids
Increased fibre and fluid intake
Soften teh stools
Anusol, lidocaine
Rubber band ligation
Acutely thromboses
- within 72hours = excision
Low albumin?
Malnutrition or liver disease
Ascending cholangitis
E coli commonly
Obstruction or infection ( post ERC)
Charcot
- RUQ pain, fever, jaundice, hypotension, confusion
USS, CT, MRCP
—-> IV abx and ERCP
Cholangiocarcinoma
Adaenocarcinoma
Obstructive jaundice, weiht loss
Staging CT, Ca19.9
Alcoholic hepatitis
AST: ALT more than 2:1
Symptomatic
–> give red
Pancreatitis
Elastase can show function
Blood glucose, hypoxia and hypocalcaemia is prognostic
Lipase has a longer half life than amylase - good in conditions >24 hours presentations