Typical antipsychotics examples and mechanism of action?
Act on dopamine d2
Haloperidol, chlorpromazine
Atypical antipsychotics examples and mechanism of action?
Act on variety of receptors - d2,d3,d4, 5HT
E.g. clozapine, risperidone, olanzapine, quetiapine
What are typical antipsychtoics used for?
Positive symptoms of schizoprenia.
Side effects of typical antipsychotics?
Extrapyramidal side effects and anticholinergic effects e.g. dry skin, blurred vision
Extrapyramidal side effects:
ADAPT - Acute dystonia, Akathisia, Parkinsonism, Tadive dyskinesia
Hyperprolactinaemia - may get galactorrhea
Side effects of atypical antipsychotics?
Weight gain and metabolic syndrome
- Obesity, HTN, impaired fasting glucose, hypertrigycleridemia, low HDL cholesterol
What is acute dystonia? Management?
Sustained muscle contraction
May be managed with procyclidine
What is akathisia?
Severe restlessness
What is tardive dyskinesia?
Late onset of choreoathetoid movements, most common is chewing and pouting of the jaw
Side effects of antipsychotics?
r Side effects
- Antimuscarinic- dry mouth, blurred vision, urinary retention, constipation.
- Sedation, weight gain
- Raised prolactin
○ May result in galactorrhoea
○ Due to inhibition of dopaminergic tuberoinfundibular pathway
- Impaired glucose tolerance
- Neuroleptic malignant syndrome - pyrexia, muscle stiffness
- Reduced seizure threshold - greater with atypicals
- Prolonged QT interval - particularly haloperidol!
How do Benzodiazapines work and what do they do?
Enhance the effect of the GABA by increasing frequency of chloride channels
Sedation
Hypnotic
Anxiolytic
Anticonvulsant
Muscle relaxant
e.g. diazepam, lorezpam
How long can you prescribe benzodiazepines for?
2-4 weeks
Can develop tolerance and dependence to benzodizapines and care should therefore be exercised on prescribing
Benzodiazepine withdrawal syndrome
May occur up to 3 weeks after stopping long acting drug
Features include:
- Insomnia
- Irritability
- Anxious
- Tremor
- Loss of appetite
- Tinnitus
- Perspiration
- Perceptual disturbances
- Seizures
Adverse effects of SSRIs
GI symptoms
Increased risk of GI bleeding - prescribe PPI if patients are also taking an NSAID
Be vigilant for increased anxiety and agitation after starting SSRI
Associated with hyponatraemia
SSRI discontinuation symptoms
Increased mood change
Restlessness
Difficulty sleeping
Unsteadiness
Sweating
GI symptoms
Paraesthesia
SSRIs drug interactions
Aspirin, NSAIDs, anticoagulants, and antiplatelets — increased risk of bleeding if taken concomitantly with SSRIs.
Triptans and MAOIs = increased risk of serotonin syndrome
TCAs - use and example?
Used widely in treatment of neuropathic pain
Inhibition of reuptake of neurotransmitters
Amityptilline
Side effects of TCAs?
What are SNRIs and examples?
Venlafaxine, Duloxetine
Serotonin AND noradrenaline
What is circumstantiality?
Inability to awnser a question without giving excessive, unnecessary details
Does eventually return to the original point
What is tangentiality?
Wondering from a topic without returning to it
What are neologisms?
New word formations
What are clang associations?
When ideas related to each other only by the factor they sound similar or rhyme
What is knights move thinking?
Severe type of loosening of associations where there are unexpected and illogical leaps from one idea to another
Feature of schizophrenia
What is preservation
Repetition of ideas or words despite an attempt to change the topic