Psych Flashcards

(192 cards)

1
Q

Typical antipsychotics examples and mechanism of action?

A

Act on dopamine d2
Haloperidol, chlorpromazine

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2
Q

Atypical antipsychotics examples and mechanism of action?

A

Act on variety of receptors - d2,d3,d4, 5HT
E.g. clozapine, risperidone, olanzapine, quetiapine

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3
Q

What are typical antipsychtoics used for?

A

Positive symptoms of schizoprenia.

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4
Q

Side effects of typical antipsychotics?

A

Extrapyramidal side effects and anticholinergic effects e.g. dry skin, blurred vision

Extrapyramidal side effects:
ADAPT - Acute dystonia, Akathisia, Parkinsonism, Tadive dyskinesia

Hyperprolactinaemia - may get galactorrhea

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5
Q

Side effects of atypical antipsychotics?

A

Weight gain and metabolic syndrome
- Obesity, HTN, impaired fasting glucose, hypertrigycleridemia, low HDL cholesterol

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6
Q

What is acute dystonia? Management?

A

Sustained muscle contraction
May be managed with procyclidine

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7
Q

What is akathisia?

A

Severe restlessness

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8
Q

What is tardive dyskinesia?

A

Late onset of choreoathetoid movements, most common is chewing and pouting of the jaw

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9
Q

Side effects of antipsychotics?

A

r Side effects
- Antimuscarinic- dry mouth, blurred vision, urinary retention, constipation.
- Sedation, weight gain
- Raised prolactin
○ May result in galactorrhoea
○ Due to inhibition of dopaminergic tuberoinfundibular pathway
- Impaired glucose tolerance
- Neuroleptic malignant syndrome - pyrexia, muscle stiffness
- Reduced seizure threshold - greater with atypicals
- Prolonged QT interval - particularly haloperidol!

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10
Q

How do Benzodiazapines work and what do they do?

A

Enhance the effect of the GABA by increasing frequency of chloride channels

Sedation
Hypnotic
Anxiolytic
Anticonvulsant
Muscle relaxant

e.g. diazepam, lorezpam

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11
Q

How long can you prescribe benzodiazepines for?

A

2-4 weeks
Can develop tolerance and dependence to benzodizapines and care should therefore be exercised on prescribing

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12
Q

Benzodiazepine withdrawal syndrome

A

May occur up to 3 weeks after stopping long acting drug
Features include:
- Insomnia
- Irritability
- Anxious
- Tremor
- Loss of appetite
- Tinnitus
- Perspiration
- Perceptual disturbances
- Seizures

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13
Q

Adverse effects of SSRIs

A

GI symptoms
Increased risk of GI bleeding - prescribe PPI if patients are also taking an NSAID
Be vigilant for increased anxiety and agitation after starting SSRI
Associated with hyponatraemia

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14
Q

SSRI discontinuation symptoms

A

Increased mood change
Restlessness
Difficulty sleeping
Unsteadiness
Sweating
GI symptoms
Paraesthesia

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15
Q

SSRIs drug interactions

A

Aspirin, NSAIDs, anticoagulants, and antiplatelets — increased risk of bleeding if taken concomitantly with SSRIs.

Triptans and MAOIs = increased risk of serotonin syndrome

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16
Q

TCAs - use and example?

A

Used widely in treatment of neuropathic pain
Inhibition of reuptake of neurotransmitters

Amityptilline

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17
Q

Side effects of TCAs?

A
  • Antagonism of histamine receptors
    ○ Drowsiness
    • Antagonism of muscarinic receptors
      ○ Dry mouth
      ○ Blurred vision
      ○ Constipation
      ○ Urinary retention
    • Antagonism of adrenergic receptors
      ○ Postural hypotension
    • Lengthening of QT interval
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18
Q

What are SNRIs and examples?

A

Venlafaxine, Duloxetine

Serotonin AND noradrenaline

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19
Q

What is circumstantiality?

A

Inability to awnser a question without giving excessive, unnecessary details
Does eventually return to the original point

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20
Q

What is tangentiality?

A

Wondering from a topic without returning to it

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21
Q

What are neologisms?

A

New word formations

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22
Q

What are clang associations?

A

When ideas related to each other only by the factor they sound similar or rhyme

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23
Q

What is knights move thinking?

A

Severe type of loosening of associations where there are unexpected and illogical leaps from one idea to another

Feature of schizophrenia

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24
Q

What is preservation

A

Repetition of ideas or words despite an attempt to change the topic

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25
What are flight of ideas?
Leaps from one topic to another but with discernible links between them
26
What is word salad?
Completely incoherent speech, where real words are strung together into nonsense sentences
27
What is acute stress disorder?
Acute stress reaction that occurs in the first 4 weeks after a person has been exposed to a trauma event **Different to PTD which is diagnosed after 4 weeks
28
What are features of an acute stress reaction?
Intrusive thoughts e.g. flashbacks and nightmares Dissociation e.g. being in a daze Negative mood Avoidance Arousal e.g. hyper vigilance and sleep disturbance
29
Management of acute stress disorder?
FIRST LINE: Trauma focused CBT Benzodiazapines - Sometimes used for acute symptoms e.g. agitation and sleep disturbance
30
What does chronic alcohol consumption do and what does withdrawal do ?
Enhances GABA mediated inhibition in CNS and inhibits NMDA glutamate receptors Alcohol withdrawal is opposite = decreased inhibitory GABA and increased NDMA glutamate transmission
31
Features of alcohol withdrawal
Symptoms start at 6-12 hours: tremor, sweating, tachy, anxiety Peak incidence of seizures at 36 hours Peak incidence of delirium tremens is at 48-72 hours - coarse tremor, confusion, delusions, auditory and visual hallucinations, fever, tahycardic
32
Management of alcohol withdrawal?
First line: long acting benzodiazepines e.g. chlordiazepoxide or diazepam Lorazepam - may be preferable if hepatic failure
33
What is a specific phobia?
Excessive fear or anxiety Consistently occurs upon exposure or anticipation e.g. fear of cat or spider Persists usually for 6 months Impaired ability to function
34
What is panic disorder?
Intermittent and without and obvious trigger Comes out of the blue Panic attacks - increased rate, chest pain, sweating, SOB, dizzy, anxious thoughts e.g. about to die.
35
Differentials for panic disorder and panic attacks
Angina, stroke, phaechromocytoma- causes paroxysmal anxiety , intoxication , withdrawal
36
Treatment for panic disorder?
CBT or SSRIs If SSRIs are contraindicated or no response within 12 weeks then imipramine or clomipramine should be offered
37
What is social anxiety disorder?
Excessive fear - can't function in normal life Occurs in one or more social situations Concerned that they will act in a way, show anxiety symptoms or negatively evaluated by others e.g. seeking in front of people
38
What is GAD?
Continuous and generalised anxiety Excessive and marked symptoms of anxiety Not restricted to anything in particular Struggle to concentrate, cant sleep, sympathetic overdrive
39
Differentials to GAD?
organic = hyperthyroidism causes anxiety symptoms Dementia - anxiety may be an early presentation Intoxication e.g. amphetamines, caffeine Withdrawal e.g. from benzodiazepines, alcohol and opiods Psychosis Depression Personality disorder
40
Management of GAD?
step 1: education about GAD + active monitoring step 2: low-intensity psychological interventions (individual non-facilitated self-help or individual guided self-help or psychoeducational groups) step 3: high-intensity psychological interventions (cognitive behavioural therapy or applied relaxation) or drug treatment. * step 4: highly specialist input e.g. Multi agency teams
41
Best SSRI post MI
Sertraline
42
SSRI used for children and adolescents
Fluoxetine
43
After initiation of SSRis - what happens?
Should be reviewed by a doctor after 2 weeks For patients under the age of 25 or at increased risk of suicide - reviewe after 1 weeks If a patient makes a good response to antidepressant therapy they should continue on treatment for at least 6 months after remission as this reduces the risk of relapse.
44
Coming off an SSRI??
Dose should be gradually reduced over a 4 week period ( not necessary with fluoxetine) Paroxetine has higher incidence of discontinuation symtpoms
45
Preffered SSRIS
Citalopram and fluoxetine
46
Caution with citalopram
QT interval lengthening and toursades de pointes
47
SSRIs and pregnancy
Use during the first trimester gives a small increased risk of congenital heart defects - Use during the third trimester can result in persistent pulmonary hypertension of the newborn - Paroxetine has an increased risk of congenital malformations, particularly in the first trimester
48
Drug treatment for GAD?
Sertraline is first line - if sertraline is ineffective, offer an alternative SSRI or a SNRI- examples of SNRIs include duloxetine and venlafaxine - If the person cannot tolerate SSRIs or SNRIs, consider offering pregabalin For patients under the age of 30 years NICE recommend you warn patients of the increased risk of suicidal thinking and self-harm. Weekly follow-up is recommended for the first month
49
What is OCD?
Time consuming persistent obsessions and/or compulsions Take up an hour a day - Obsessions = intrusive, unwanted, repetitive thoughts - Compulsions = repetitive behaviours or mental acts that they are driven to perform to neutralise the obsession e.g. washing hands, repeating words or phrases
50
What is ego-dystonic OCD?
Conflict uncomfortably with the person's self image, and are in no way enjoyable E.g. contamination and illness, sex e.g. fear of being a paedophile( when this feels repungent), need for order or symmetry
51
Management of anxiety disorders?
Antidepressants - SSRIs e.g. sertraline SNRIs e.g. venlafaxine TCAs e.g. imipramine - avoid if suicidal, as toxic in overdose Anxiolytics - pregablin- GAD Benzodiazepines e.g. diazepam - short term anxiety.. But mustn't exceed 2-4 weeks. Beta blockers e.g. atenolol, propranolol CBT Psychoeducation
52
Hyperthyroidism and anxiety Link?
Continuous anxiety TFTs investigation
53
What things produce a continuous anxiety pattern?
Hyperthyroidism Caffeine Alcohol
54
What things produce an episodic anxiety pattern?
Caffeine Alcohol Recreational drugs Arrhythmia Hypoglycaemia Phaeochromocytoma
55
OCD - key difference to psychosis?
The thoughts CAN be shakeable
56
Risk factors for OCD?
Family history Peak onset age is between 10-20 Pregnancy/postnatal History of abuse, bullying and neglect
57
Management for OCD?
Classifying to mild, moderate or severe Use of Y-BOCs scale Treat accordingly Mild - CBT, ERP ( exposure and response prevention) SSRI if doesnt wrok Moderate - SSRI or more intensive CBT with ERP If severe 0 SSRI and CBT and ERP, refer to secondary care. If the SSRI is effective continue it for at least 12 MONTHS! Note: SSRI is higher dose than for depression and must be continued for 12 months
58
What SSRI is used for OCD in body dysmorphic disorder?
Fluoxetine
59
What is somatisation disorder?
Multiple physical symptoms present for at least 2 years Patient refuses to accept reassurance or negative test results
60
What is Illness anxiety disorder - hypochondriasis?
Persistent belief in the presence of an underlying serious disease e.g. cancer patient refuses to accept reassurance or negative test results
61
What is functional neurological disorder (conversion disorder) ?
Typically involves loss of motor or sensory function Patient doesn't consciously feign the symptoms (factitious disorder) or seek material gain (malingering)
62
What is dissociative disorder?
Separating off certain memories from normal consciousness Involves psychiatric symptoms e.g. amnesia
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What is factitious disorder?
Münchausen's syndrome Intentional production of physical or psychological symptoms
64
What is malingering?
Fraudulent stimulation or exaggeration of symptoms with the intention of financial or other gain
65
Features of PTSD?
Symptoms must have been present for more than one month re-experiencing: flashbacks, nightmares, repetitive and distressing intrusive images avoidance: avoiding people, situations or circumstances resembling or associated with the event hyperarousal: hypervigilance for threat, exaggerated startle response, sleep problems, irritability and difficulty concentrating emotional numbing - lack of ability to experience feelings, feeling detached from other people depression drug or alcohol misuse anger unexplained physical symptoms
66
Risk factors for PTSD?
neuroticism, personal or family history of psychiatric problems, childhood abuse, poor early attachment
67
Diagnosis of PTSD?
Trauma screening questionnaire is used Diagnosis based on criteria from DSM5 or ICD11
68
Management of PTSD?
Watchful waiting may be used for mild symptoms lasting less than 4 weeks Military personnel have access to treatment provided by the armed forces CBT or EMDR ( eye movement desensitisation and reprocessing) therapy may be used in more severe cases Venlafaxine (SNRI) or sertraline ( SSRI) or risperidone ( antipsychotic)
69
What is ADHD and what does it result from?
Difficulty maintaining attention, excessive energy and activity and impulsivity More than twice as common in males ---> genetic, pregnancy related factors ( e.g. maternal smoking, premature birth and low birth weight), environmental factors Symptoms commonly start at childhood and should be consistent across settings!
70
Features of ADHD?
- Short attention span - Easily distracted - Quickly moving from one activity to another - Quickly losing interest in task - Inability to persist with and complete tasks - Constantly moving or fidgeting - Impulsive behaviour - Disruptive behaviour - Difficulty managing time
71
Management of ADHD?
Managing strategies for parents include: * A positive approach * Structured routines * Clear boundaries * Plenty of physical activity * A healthy diet (certain foods may exacerbate the symptoms) Self-management strategies for adults to help manage symptoms include organisation techniques, a healthy diet, exercise, and a sleep routine. Reasonable adjustments to the workplace may be helpful. Medication is an option after conservative management has failed, or in severe cases: Central nervous system stimulants e.g.: * Methylphenidate (Ritalin) * Lisdexamfetamine * Dexamfetamine * Atomoxetine Monitoring requirements whilst taking medications include heart rate, blood pressure, weight and mood changes.
72
Features of autism spectrum disorder?
Vary between individuals along the spectrum Deficits in social interaction, communication and behaviour Features usually observable before the age of 3
73
What is autism spectrum disorder?
Impairments in social interaction, communication and behaviour Defined in the DSM-5 Asperges = difficulty in reading emotions and responding to others.
74
How does deficits in social interaction in autism present ?
Lack of eye contact, delay in smiling, avoiding physical contact, unable to read non verbal cues, difficulty establishing friendships, not displaying a desire to share attention
75
How does deficits in communication present in autism?
Delay, absence or regression in language development, lack of appropriate non verbal communication, difficulty with imaginative or imitative behaviour, repetitive use of words or phrases
76
How does deficits in behaviour in Autism present?
Greater interest in objects, numbers or patterns than people Stereotypical repetitive movements e.g. self stimulating- hand flapping, rocking Intense and deep interests that are persistent and rigid Repetitive behaviours and fixed routines Anxiety and distress with experiences outside their regular routine Extremely restricted food preferences
77
Management of autism?
Depends on severity Non pharmacological therapy; - Early educational and behavioural interventions: applied behavioural analysis, ASD preschool programme, Pharmacologic interventions: no consistent evidence - SSRIS may be helpful to reduce symptoms like repetitive stereotypesd behaviour, anxiety and aggression Antipsychotics can be used to reduce aggression and self injury Methylphenidate for ADHD
78
What is Bipolar affective disorder?
Chronic mental health disorder characterised by periods of mania/hypomania alongside epodes of depression
79
2 types of bipolar affective disorder?
Type 1: mania and depression - involves at least 1 episode of mania Type 2: hypomania and depression involves at least one episode of major depression and 1 of hypomania
80
What is cyclothymia?
Midler symptom of hypomania and low mood, symptoms not severe enough to impair function
81
What is unipolar depression?
Only episodes of depression without hypomania or mania
82
What is mania?
Abnormally elevated mood/irritability Severe functional impairment or psychotic symptoms for 7 days or more Psychotic symptoms e.g. delusions of grandeur/auditory hallucinations suggest mania
83
What is hypomania?
Abnormally elevated mood/irritability Decreased or increased function for 4 days or more Psychotic symptoms e.g. delusions of grandeur/auditory hallucinations suggest mania
84
Treatment options for an acute manic episode?
- Antipsychotic medications (e.g., olanzapine, quetiapine, risperidone or haloperidol) are first-line - Other options are lithium and sodium valproate - Existing antidepressants are tapered and stopped
85
Management of mania?
Psychological: lithium ( mood stabiliser). Serum lithium level - taken 12 hours after most recent dose- are closely monitored to ensure dose is correct. Usual initial target range = 0.6-0.8 mmol/L Alternative- sodium valproate (NOTE: THIS IS TERATOGENIC ) Consider stopping antidepressant if the patient takes one. Antipsychotic therapy e.g. olanzapine or haloperidol
86
Signs of lithium toxicity?
Fine tremor, weight gain, CKD, hypothyroidism and goitre, hyperparathyroidism, hypercalcaemia, nephrogenic diabetes inspidius.
87
Management of depression in bipolar
Talking therapies, fluoxetine is the antidepressant of choice Address co-morbidities there is a 2-3 times increased risk of diabetes, cardiovascular disease and COPD
88
What is BPSD?
Behavioural and psychological symptoms of dementia. Neuropsychiatric symptoms that accompany the syndrome of dementia such as delusions, hallucinations, apathy, anxiety, depression and inhibition
89
5 domains of dementia?
Cognitive/perceptual e.g. delusions and hallucinations Motor e.g. pacing, wandering, repetitive movements, physical aggression Verbal e.g. yelling, calling out, repetitive speech, verbal aggression Emotional e.g. euphoria, depression, apathy, anxiety, irritability Vegetative e.g. disturbances in sleep and appetite
90
Steps to manage BPSD?
Treating underlying causes (e.g., pain, constipation or urinary retention) Environmental factors (e.g., providing a calming setting and removing triggers) Appropriately trained carers Appropriate supervision (one-to-one observation may be required) Music therapy Medication options for managing BPSD are only used where necessary and cause significant side effects. Options include: * SSRI antidepressants for depressive symptoms * Antipsychotic drugs (typically risperidone first-line) * Benzodiazepines (only for crisis management)
91
What is depression?
Disturbance in the neurotransmitter activity in the CNS- particularly serotonin low mood and anhedonia - lack of pleasure or interest in activities. emotional, cognitive and physical symptoms
92
Explain the key symptoms of depression inc categories they fall into?
Emotional symptoms: - Anxiety - Irritability - Low self esteem - Guilt - Hopelessness about the future Cognitive symptoms: - Poor concentration - Slow thoughts - Poor memory Physical symptoms: - Low energy - TATT - Abnormal sleep - early morning waking - Poor appetite or overeating - Slow movements
93
How to assess severity of depression?
PHQ-9 score 9 questions about how often the patient is experiencing symptoms in the past 2 weeks Higher score = more severe depression 5-9 = mild 10-14 = moderate 15-19 = moderately severe 20-27 = severe depression <16 = less severe, >16 = more severe
94
Management of less severe depression?
Treatment options, listed in order of preference by NICE: * guided self-help * group cognitive behavioural therapy (CBT) * group behavioural activation (BA) * individual CBT * individual BA * group exercise * group mindfulness and meditation * interpersonal psychotherapy (IPT) * selective serotonin reuptake inhibitors (SSRIs) * counselling * short-term psychodynamic psychotherapy (STPP)
95
Management of more severe depression?
Treatment options, listed in order of preference by NICE: * a combination of individual cognitive behavioural therapy (CBT) and an antidepressant * individual CBT * individual behavioural activation (BA) * antidepressant medication ○ selective serotonin reuptake inhibitor (SSRI), or ○ serotonin-norepinephrine reuptake inhibitor (SNRI), or ○ another antidepressant if indicated based on previous clinical and treatment history * individual problem-solving * counselling * short-term psychodynamic psychotherapy (STPP) * interpersonal psychotherapy (IPT) * guided self-help * group exercise
96
Switching from citalopram, escitalopram, sertraline or paroxetine to another SSRI?
Direct switch is possible
97
Switching from fluoxetine to another SSRI
Withdrawal then leave a gap of 4-7 days ( as it has a long half life), before starting a low dose of the alternative SSRI
98
Switching from an SSRI to a TCA?
Cross tapering recommended - current drug dose is reduced slowly and new drug dose is increased slowly.
99
Switching from fluoxetine to venlafaxine
Withdraw and then start venlafaxine at low dose 4-7 days later
100
3 types of dissociative disorders?
Depersonalisation- derealisation = feeling of being separated or outside their body Dissociative amnesia - forgetting autobiographical information, typically following traumatic experience and leading to gaps in memory Dissociative identity disorder - previously called multiple personality, lack of clear individual identity -multiple separate identities, with unique names, personalities and memories. Often associated with severe stress and trauma in childhood
101
What is Catatonia?
Abnormal movement, communication and behaviour Awake but abnormal behaviour May hold unusual postures, perform odd actions etc Most common causes = severe depression, bipolar
102
What is relative attachment disorder?
Results from severe neglect and trauma in early childhood. Results in emotional withdrawal and inhibition, sadness, fearfulness, irritability
103
What is factitious disorder ( Munchausen )?
Conscious effort to fake illness and seek medical attention for personal gain SYmptoms are invented, exaggerated or induced- may induce harm. Repeated presentations with inconsistent and dramatic symptoms that don’t fit with examination findings
104
What is hoarding disorder?
Excessive accumulation of possessions and emotional difficulty getting rid of items Lack of insight
105
What is FND?
Functional neurological disorder Sensory and motor symptoms, not explained by any neurological disease, and may be caused by underlying psychosocial factors Symptoms include weakness, gait disturbance, seizures, sensory loss and visual disturbances
106
What are baby blues?
Seen in 50% of women in first week or so after birth Mood swings, low mood, anxiety, irratibility, tearfulness Symptoms mild, no treatment
107
What are baby blues?
Seen in 50% of women in first week or so after birth Mood swings, low mood, anxiety, irratibility, tearfulness Symptoms mild, no treatment
108
What is postnatal depression?
Seen in 1 in 10 women, with a peak around 3 months after birth Similar to depression - low mood, anhedonia, low energy Symptoms should last at least 2 weeks before postnatal depression is diagnosed Treatment similar to depression
109
What is puerperal psychosis?
Seen in 1 in 1000 women Starts a few weeks after birth Psychosis symptoms - delusions, hallucinations, depression, mania, confusion and thought disorder URGENT assessment needed.?ECT, medications and admission
110
What is the Edinburgh postnatal depression scale?
Assessing how mother has felt for the past week 10 questions, 30 points and more than 10 indicates postnatal depression
111
What is ECT?
Treatment option for patients with severe depression refractory to medication e.g. catatonia or those with psychotic symptoms
112
What is the absolute contraindication to ECT?
Raised ICP.
113
Short and long term side effects to ECT?
SHORT TERM Headache, nausea, short term memory impairment, memory loss of events prior to ECT, cardiac arrhythmia LONG TERM - impaired memory
114
Short and long term side effects to ECT?
SHORT TERM Headache, nausea, short term memory impairment, memory loss of events prior to ECT, cardiac arrhythmia LONG TERM - impaired memory
115
Restricted eating disorder blood test findings?
Anaemia, leukopenia (low WBC) , thrombocytopenia (low platelets), hypokalaemia - low potassium due to vomiting or excessive laxatives Reduced bone marrow activity NORMOCYTIC NORMOCHROMIC anaemia
116
Physiological abnormalities - anorexia
Hypokalaemia Low FSH, LH, oestrogen and testosterone Raised cortisol and GH Impaired glucose toleranc e Hypercholesterolaemia Hypeorcarotenaemia Low T3
117
Features of anorexia?
Reduced body mass index Bradycardia Hypotension Enlarged salivary glands Amenorrhea- absent periods, due to disruption of HPG axis. Lack of gonadotrophins (LH and FSH) from the pituitary, = reduced activity of the ovaries ( hypogonadism) Cardiac complications Low bone mineral density Hypotension Languago hair - fine, soft hair across most of the body
118
Diagnosing anorexia nervosa?
3 things: 1. restriction of energy intake relative to requirements leading to SIGNIFICANTLY low body weight in the context of age, sex, developmental trajectory and physical health. 2. intense fear of gaining weight or becoming fat, even though underweight 3. Disturbance in the way in which one's body weight or shape is experiences, undue influence of body weight or shape on self evaluation or denial of the seriousness of current low body weight
119
Management of anorexia nervosa?
Adults - individual eating disorder focused CBT ( CBT-ED) Children and young people - Anorexia focused family therapy is first line - CBT is second line
120
What is bulimia nervosa?
Recurrent episodes of binge eating followed by intentional vomiting, or other purgative behaviours e.g. laxatives/diuretics/exercising
121
Diagnostic criteria for bulimia nervosa?
Recurrent episodes of binge eating Sense of lack of control over eating during binge eating Recurrent inappropriate compensatory behaviour in order to prevent weight gain Recurrent vomiting may lead to erosion of the teeth and Russels sign = calluses on the knuckles or back of hand due to repeated self induced vomiting Binge eating and compensatory behaviours occur at least once a week for 3 MONTHS
122
Features ( physical) of bulimia nervosa?
Swollen salivary glands Mouth ulcers GORD Often normal weight though
123
Management of bulimia nervosa?
Referral for specialist care Bulimia nervosa focused guided self help If ineffective after 4 weeks - CBT-ED Children - bulimia nervosa focused family therapy
124
What are some screening tools for alcohol consumption?
AUDIT C for identification SAD Q for severity CEWA for severity of alcohol withdrawal
125
treatment of heroin dependency?
Methadone Buprenorphine
126
What is referring syndrome ?
When someone with an extended severe nutritional deficit resumes eating. Hypomagnesaemia Hypokalaemia Hypophosphataemia Fluid overload (due to water following the extra sodium into the extracellular space) RISK OF ARRHYTHMIA AND HF
127
Mechanisms behind refeeding syndrome?
During prolonged starvation, intracellular potassium, phosphate and magnesium are depleted. Electrolytes move from inside to outside the cells (into the blood), to maintain normal serum levels in the absence of dietary intake. Cell metabolism reduces to conserve energy = loss of intracellular electrolytes ( Sodium potassium ATP slows- usually pumps potassium into the cell and sodium out) During re-feeding - various mechanisms shift magnesium, potassium and phosphate out of the blood and sodium into the blood. Carbohydrate intake causes an increase in insulin, which drives glucose, potassium and phosphate into cells. Sodium/potassium ATP pump actively pumps potassium into the cells and sodium out of the cells. Insulin causes extra sodium reabsorption into the kidney.
128
Management of Re-feeding syndrome?
* Slowly reintroducing food with limited calories * Magnesium, potassium, phosphate and glucose monitoring * Fluid balance monitoring * ECG monitoring in severe cases Supplementation with electrolytes and vitamins, particularly B vitamins and thiamine
129
What are personality disorders?
Maladaptive personality traits that cause significant psychosocial distress and interfere with functioning Characterised by patterns of thought, behaviour and emotion that differ from what is normally expected. Genetic and environmental factors
130
Describe the symptoms of BPD/EUPD?
- Strong and intense emotions (e.g., anger) - Emotional instability (rapidly changing emotions) - Difficulty managing emotions - Difficulty maintaining relationships - Poor sense of identity - Feelings of emptiness - Fear of abandonment - Impulsive and risky behaviour - Recurrent self-harm - Recurrent suicidal behaviours
131
What are the clusters of personality disorders?
Cluster A: Suspicious, odd, eccentric - paranoid, schizoid, schizotypal Cluster B: Emotional or impulsive - antisocial, borderline, histrionic, narcissistic Cluster C: Anxious and fearful - obsessive-compulsive, avoidant, dependent
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What are the personality disorders in Cluster A?
Paranoid - Hypersensitivity and unforgiving attitude when insulted - Unwarranted tendency to questions the loyalty of friends - Reluctance to confide in others - Preoccupation with conspirational beliefs and hidden meaning Schizoid - Indifference to praise and criticism - Preference for solitary activities - Lack of interest in sexual interactions - Lack of desire for companionship - Emotional coldness - Few interests Schizotypal - Ideas of reference - Odd beliefs and magical thinking - Unusual perceptual disturbances - Paranoid ideation and suspiciousness - Odd, eccentric behaviour - Lack of close friends other than family members
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What personality disorders are in cluster B?
Antisocial - Failure to conform to social norms e.g. repeatedly performing acts that are ground for arrest - More common in men - Deception, lying - Impulsiveness or failure to plan ahead - Irritability and aggressiveness - Lack of remorse Borderline - emotionally unstable - Efforts to avoid real or imagined abandonment - Unstable interpersonal relationships which alternate between idealisation and devaluation - Unstable self image - Chronic feelings of emptiness - Difficulty controlling temper - Impulsivity in potentially self damaging areas e.g. spending, sex, substance abuse Histrionic - Inappropriate sexual seductiveness - Need to be centre of attention - Rapidly shifting and shallow expression of emotions - Suggestibility - Physical appearance used for attention seeking Narcissistic - Grandiose sense of self importance - Preoccupation with fantasies of unlimited success, power or beauty - Sense of entitlement - Lack of empathy - Excessive need for admiration - Chronic envy - Arrogant and haughty attitude
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What personality disorders are in cluster C?
Obsessive compulsive - Occupied with details, rules, lists, order, organisation - Demonstrates perfectionism that hampers with completing tasks - Dedicated to work and efficiency to the elimination of spare time activities - Meticulous, scrupulous and rigid about etiquettes of mortality, ethics or values - Not capable of disposing worn out or insignifican thtings - Stingy, stiffness, stubborness Avoidant - Avoidance of occupational activities which involve significant interpersonal contact due to fears of criticism or rejection - Unwillingness to be involved unless certain of being like d - Preoccupied with ideas they are being criticised or rejected in social situations - Restraint in intimate relationships due to fear of being ridiculed Dependent - Difficulty making everyday decisions without excessive reassurance from others - Need for others to assume responsibility for major areas of their life - Lack of initiative Difficulty in expressing disagreement with others due to fears of loosing support
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Management of personality disorders?
- Psychological treatment - DBT - Risk management Sometimes sedative medications are used in short term in crisis.
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What are features of psychosis?
- Hallucinations - visual, auditory- voices talking about/to .. External to own thoughts , olfactory , tacticle hallucinations - bugs crawling on you etc - Delusions - unshakeable, out of context with culture/ religion etc - Thought disorganisation ○ Alogia - little info conveyed by speech ○ Tangentiality - answers diverge from topic ○ Clanging ○ Word salad - linking real words incoherently
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What conditions can cause psychotic symptoms?
- Schizophrenia - Depression - Bipolar disorder - Puerperal psychosis - Brief psychotic disorder: where symptoms last less than a month - Neurological conditions e.g. Parkinson's disease, Huntington's disease, stroke, brain tumours - Hyperthyroidism - Psychotic depression - Prescribed drugs e.g. corticosteroids - Certain illicit drugs e.g. cannabis, phencyclidine - Cushing's syndrome - and taking systemic steroids
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Peak age of first episode psychosis?
15-30 years
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What is a section 2?
Admission for assessment for up to 28 days, not renewable Approved mental health professional + 2 doctors. Treatment can be given against a patients wishes
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What is a section 3 ?
Admission for treatment for up to 6 months, can be renewed. Approved mental health professional + 2 doctors Treatment can be given against a patients wishes
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What is a section 4?
72 hour assessment Used as an emergency, when a section 2 would involve an unacceptable delay. GP and a AMHP. Often changed to section 2 upon arrival to hospital
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What is a section 5(2)?
A patient who is a voluntary patient in hospital can be legally detained by a doctor for 72 hours.
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What is a section 5(4)?
Similar to a section 5(2), allows a nurse to detain a patient who is voluntarily in hospital for 6 hours
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Section 17a?
Supervised community treatment. Can be used to recall a patient to hospital for treatment if they do not comply with conditions of the order in the community, such as complying with medication
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What is a section 135?
Court order to allow the police to break into property to remove a person to a place of safety
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What is a section 136?
Someone found in a public place who appears to have a mental disorder can be taken by the police to a place of safety Can only be used for up to 24 hours, whilst a MHA assessment is arranged.
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What is schizophrenia?
Long term, severe mental health disorder characterised by psychosis. Often presents between the ages of 15-30 and earlier in men than women Symptoms must be present for at least 6 months before schizophrenia is diagnosed Strongest risk factor is family history.
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What is schizoaffective disorder?
Combines the symptoms of schizophrenia with bipolar disorder Psychosis + depression and mania.
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What is schizophreniform disorder?
Presents with the same features of schizophrenia but lasts less than 6 months.
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Factors associated with poor prognosis - schizophrenia.
Strong family history Gradual onset Low IQ Prodromal phase of social withdrawal Lack of obvious precipitant
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Presentation of psychosis?
Prodrome phase often precedes the full symptoms of psychosis Delusions, hallucinations, thought disorder lack of insight - lacking of awareness that delusions and hallucinations are not based in reality.
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What is the prodrome to psychosis?
Subtle symptoms e.g. poor memory, reduced concentration, mood swings, suspicion of others, loss of appetite, difficulty sleeping, social withdrawal and decreased motivation
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Positive symptoms of schizophrenia?
- Auditory hallucinations - Somatic passivity - believing that an external entity is controlling their sensations and actions - Thought insertion or withdrawal or broadcasting - Thought broadcasting - believing others are overhearing their thoughts - Persecutory delusions - false belief that a person or group is going to harm them - Ideas of reference - false belief that unconnected events or details in the world directly relate to them - Delusional perceptions - Occurs when patient experiences an ordinary and unremarkable perception e.g. cat crossing the road that triggers a sudden, often self related delusion e.g. the traffic light is green therefore I am the king - Passivity phenomena- bodily sensations being controlled by an external influence, actions/impulses/feelings imposed on the individual - Neologisms - made up words - Catatonia
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Negative symptoms of schizophrenia?
Affective flattening - minimal emotional reaction to emotive subjects or events Alogia - poverty of speech - reduced speech Anhedonia - lack of interest in activities Avolition - lack of motivation in working towards goals or completing tasks
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Patterns of psychosis?
The active phase symptoms may be: Continuous, episodic (relapsing and remitting) , a single episode only
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First rank symptoms of psychosis?
ABCD A- Auditory hallucinations, hearing own thoughts spoken aloud hearing voices talking about you in 3rd person, hearing voices talking about you B- Broadcast C- Control D- Delusional perception
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Diagnosis of schizophrenia?
Based on the DSM5 criteria Symptoms including prodrome phase must have been present for at least 6 months, with symptoms of the active phase (delusions, hallucinations and thought disorder) present for at least 1 month (or less if treatment is successful).
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Management of schizophrenia?
- Early intervention in psychosis services are available for the first episodes of psychosis - Crisis resolution and home treatment teams - urgent support in crisis - Second generation antipsychotic +long acting benzodiazepine in hospital - Acute hospital admission when required - Community mental health team for ongoing management and monitoring - Oral ATYPICAL ANTIPSYCHOTICS second gen are first line CBT offered to all
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What do you give in schizophrenia when 2 antipsychotics dont work?
Clozapine
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What to give in schizophrenia when adherence is an issue?
Depot antipsychotics given as an IM injection every 2 weeks- 3 months
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What is neuroleptic malignant syndrome?
Potentially life threatening complication of antipsychotics Muscle rigidity, hyperthermia, altered consciousness, autonomic dysfunction - fluctuating BP and tachycardia
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Key blood test findings of neuroleptic malignant syndrome?
Raised CK Raised WBC- leucocytosis
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Management of neuroleptic malignant syndrome?
Stopping the causative medications and supportive care e.g. IV fluids and sedation with benzodiazepines. Severe cases may require treatment with bromocriptine or dantrolene
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What is clozapine used for? ( schizo)
When other treatment doesn't control symptoms Often taken by mouth
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Key things to note re clozapine?
Smoking changes can destabilise clozapine levels SIDE EFFECTS !!! - close monitoring is required. Agranulocytosis - severely low neutrophil count - predisposing to severe infection. Myocarditis or cardiomyopathy Constipation Seizures Excessive salivation
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What are protective factors against suicide?
- Social support - Religious belief - Children at home Regretting an attempt
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What are risk factors for suicide?
- Male - History of deliberate self harm - Alcohol or drug misuse - History of mental illness ○ Depression ○ Schizophrenia - History of chronic disease - Advancing age - Unemployment or social isolation/living alone - Being unmarried, divorced or widowed
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Cycle of self harm?
1. Emotional suffering 2. Emotional overload 3. Panic 4. Self harming 5. Temporary relief 6. Shame and guilt
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Presenting features that increase risk of suicide?
- Previous suicidal attempts - Escalating self harm - Impulsiveness - Hopelessness - Feelings of being a burden - Making plans - Writing a suicide note
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How to calculate alcohol units?
Volume(ml) x alcohol content (%) /1000
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What is the recommended alcohol consumption?
No more than 14 units per week Spread evenly over 3 or more days Not more than 5 units in a single day
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Binge drinking
Single session involving 6/8 or more units
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Examination findings with excess alcohol?
Smelling of alcohol Slurred speech Bloodshot eyes Dilated capillaries on the face ( telangiectasia) Tremor
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Blood results for excess alcohol?
* Raised mean corpuscular volume (MCV) * Raised alanine transaminase (ALT) and aspartate transferase (AST) * AST:ALT ratio above 1.5 particularly suggests alcohol-related liver disease *Raised gamma-glutamyl transferase (gamma-GT) (particularly notable with alcohol-related liver disease)
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Alcohol withdrawal symptoms ?
* 6-12 hours: tremor, sweating, headache, craving and anxiety * 12-24 hours: hallucinations * 24-48 hours: seizures * 24-72 hours: delirium tremens
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What are delirium tremens?
Medical emergency associated with alcohol withdrawal Under functioning of GABA and over functioning of glutamate system = extreme excitability and excessive adrenergic activity
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Presentation of delirium tremens?
* Acute confusion * Severe agitation * Delusions and hallucinations * Tremor * Tachycardia * Hypertension * Hyperthermia * Ataxia (difficulties with coordinated movements) Arrhythmias
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What is treatment for managing alcohol withdrawal?
Chlodiazepozide Pabrinex (high dose B vitamins) and then long term thiamine
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Long term management for alcohol dependence?
* Specialist alcohol service involvement * Alcohol detoxification programme * Oral thiamine to prevent Wernicke-Korsakoff syndrome * Psychological therapy (e.g., cognitive behavioural therapy) * Acamprosate, naltrexone or disulfiram are medications used to help maintain abstinence * Informing the DVLA (their driving licence will be revoked until an extended period of abstinence)
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Features of Wernicke-Korsakoff syndrome?
Confusion Ocuomotor distrubances Ataxia ( difficulties with coordinated movements)
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Features of Korsakoff syndrome?
Memory impairment Behavioural change
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Investigations for Wenickes encephalopathy?
* decreased red cell transketolase * MRI
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Bullimia presentation
metabolic alkalosis. The low chloride suggests the cause of this metabolic alkalosis is loss of hydrochloric acid from the stomach (through vomiting). Severe vomiting would also account for the hypokalaemia shown on ECG( Tall P and flatterned T) The lack of acute nausea and vomiting suggests that the vomiting may be a long standing issue and therefore bulimia nervosa is a likely diagnosis unless she has a past medical history of another condition which could account for persistent vomiting.
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Zopiclone risk
Increased risk of falls in elderly
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What is amitryptilline and name some side effects?
TCA drowsiness dry mouth blurred vision constipation urinary retention antagonism of adrenergic receptors postural hypotension lengthening of QT interval
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Avoidant vs schizotypal vs schizoid vs antisocial
Antisocial = criminal schizotypal = odd beliefs and magical thinking, ideas of reference with retained insight and odd behaviour schizoid = solitary behaviour, indifference or lack of interest towards others and being affectively detacheD. WANTS TO BE ALONE avoidant = Alone but doesnt want to be - feels inferior
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How long should you continue on SSRIs for?
6 months
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Why might mirtazapine be prescribed?
Mirtazapine may be prescribed due to useful side effects (sedation and increased appetite) SSRI
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Conversion vs dissociative disorder?
Conversion disorder is loss of function with no cause. Dissociative disorder is similar, but is when the loss of function is non-physical, for example loss of memory.
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What is malingering?
Malingering is faking symptoms in order for personal, usually financial, gain. There is no sign that this woman is looking for financial compensation.
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What is Delusional parasitosis?
Delusional parasitosis is a rare condition in which patients present with a fixed, false belief that they are infected by bugs. Although it may present in conjunction with other psychiatric disorders, it may present in isolation, and leave patients relatively functionally unimpaired, as in this case.
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Acute dystonia from antipsychotics?
sustained muscle contraction (e.g. torticollis, oculogyric crisis) may be managed with procyclidine