Lecture 10

Question 1

What granulocyte responds to bacteria ?

Answer 1

neutrophils

Question 2

What type of granulocyte responds mainly to parasites and allergens?

Answer 2

eosinophils

Question 3

What granulocyte responds mainly to allergic and anaphylactic reactions

Answer 3

Mast cells

Question 4

What granules are released by mast cells and what is the function of them?

Answer 4

1. Heparin = prevent thrombosis + blood stasis
2. Histamine = vascular permeability, chemoattractant-neutrophils and eosinophils
3. Leukotrienes = vascular permeability & smooth muscle contraction

Question 5

What is the difference between a monocyte and a macrophage?

Answer 5

Monocyte = blood macrophages 
Macrophages = in tissue

Question 6

What are the three different types of T-cells and what are the functions of them?

Answer 6

• CD4+ Th1 cells – antiviral
• CD4+ Th2 cells – allergy and parasites
• CD8+ cytotoxic t-cells = kill virally infected cells

Question 7

What is the process that is involved in phagocytosis?

Answer 7

1. Recognition and attachment
2. Engulfment - ingested into a phagosome
3. Killing and degranulation as the lysozyme fuses with phagosome

Question 8

What are the two different types of chemotaxis migration signals?

Answer 8

1. Exogenous- Bacterial products (peptides, LPS)

2. Endogenous- Chemokines