Microcirculation

Question 1

directionality at capillary level

Answer 1

bidirectional

Question 2

which organ is more sensitive to arterial and venous pressures that other tissues?

Answer 2

kidney

Question 3

pulmonary arterial pressure is (higher/lower) than pulmonary capillary pressure

Answer 3

extremely higher

Question 4

pulmonary capillary pressure is (higher/lower) than pulmonary venous pressure

Answer 4

higher

Question 5

T/F

Pc is relatively insensitive to ∆ Art BP (kidney exception)

Answer 5

true;

↑ Arterial BP
→ Arterioles constrict (myogenic response)
→ Capillary pressure changes very little

Question 6

T/F

Pc is moderate to highly sensitive to ∆ Ven BP

Answer 6

true

Question 7

formula for transcapillary flow?

Answer 7

Question 8

Pc is (greater or lower) than Pi?

Answer 8

greater

Question 9

if the net value of transcapilalry flow is positive, the flow is

Answer 9

moving out of capillary

Question 10

lymph fluids are high in

Answer 10

lymphocytes and triglycerides

Question 11

Pi is often negative because of

Answer 11

the suction effect via pumping+one way valve

Question 12

fluids tend to move

Answer 12

into the capillary as oncotic pressure of capillary is higher

Question 13

If flow into the capillary increases or decreases, what would be expected to change ..

Answer 13

Pc would be expected to change

Question 14

If flow out of the capillary increases or decreases

Answer 14

Pc would be expected to change

Question 15

If blood albumin concentration increases or decreases

Answer 15

Question 16

If lymphatic drainage increases or decreases

Answer 16

Question 17

If systemic venous blood pressures rise…

Answer 17

Question 18

If pulmonary venous blood pressures rise…

Answer 18

Question 19

If capillary permeability to water or surface area changes…

Answer 19

Question 20

edema occurs when

Answer 20

capillary outflow exceeds lymphatic drainage

Question 21

lungs are fairly resistant to edema bc

Answer 21

they have higher lymphatic draining ability

pulmonary venous pressure need to ncrease by about 4x or more to cause edema

Question 22

T/F

if LA pressure increases very high acutely, lymphatics in lungs cannot respond well

Answer 22

True; lungs need time to adapt to the increase

Question 23

T/F

in most tissues, giving hypertonic saline to decrease capillary [H2O] does not work

Answer 23

True; in most tissues, solutes can cross the membrane freely, so it will be ineffecive

Question 24

Would IV infusions of hypertonic saline be able to reduce brain edema?

Answer 24

YES!

because most solutes like Na+ cannot freely move thru the BBB → only draw water

Question 25

Increasing circulating ANP will ---the capillary fluid flow

Answer 25

increase the flow into the interstitium ↑ ANP → ↑ capillary permeability to water (increase K)