cvs-pharma

Question 1

all patint with htn can take wich drug

Answer 1

-2druge=acei or arbi and duritcs but

ممنوع عند كل انواع الامراض اصلا bb=prevented in HF decompensated+primar htn and asthma +not prefer in dm =mask hypoglycima symptoms
hf cant take ccb

Question 2

what type of pt u treat in htn

Answer 2

primary
asthma
pregnancy
dm
hf

Question 3

bb /se

Answer 3

mask hypoglycimia
contraindiction on cardiogenic shoch and decompensated hf
forbiden in asthmatic pt un less selective

Question 4

asthma htn drug to avoied

Answer 4

bb non selctive

acei causeing cough

Question 5

moa neprilisin(metalloprotase) inhibetor drug

Answer 5

neprilisin breaks anp and bnp and angiotension
ادوية HF بكسرو بطريقهم الangiotension=بنزل الضغط

Question 6

ccb types?

Answer 6

dihydropyramdie (vasculer sm relax)
non dihydropyramide (cardic muscle relax)

Question 7

ccb se

Answer 7

gungival hyperplasia –to much water due to vasodilation

dihydro(vasculer-edema)– periphral edema-flushing-dizznes

non dihydro(cardic)–cardic depression- av block - constipation

Question 8

hydralyzin moa

Answer 8

c gmp in sm - sm relaxent

Question 9

hydralyzin clincal use

Answer 9

saver htn and HF save to use in pregnacy

Question 10

hydralyzin se

Answer 10

headach- tachycardia-fluied retentionبسبب الvasodilation
-angina

Question 11

ccb /clincal use

Answer 11

dihydro(sm relax)—nimodapin=subarchanoid hemorrag
clvadpin+ necardpin=emargancy htn

nondihydro (cardic)=vepramil +detlizam= antiarrthmic وتحد عنده arthmia بنقله لاتموت

Question 12

which drug uses in emargency htn+moa for each

Answer 12

nicardpin+ cleavadpin(ccb) can be use with htn urgency
fandoplam(D1 agoinst direct gs stmulat-vasodilation) +nutropsuss(increas cgmp-no relas -vasodilation)
labetalol (bb)+

Question 13

arabs stand for?

Answer 13

Angiotensin II Receptor Blockers

Question 14

nitrets moa

Answer 14

increas of c gnpx- increases no –direct vasodilation

Question 15

clical use of nitrets

Answer 15

angina /plumonary edmaلانها بتقلل الperload/ acut coronary syndrom

Question 16

nitret se

Answer 16

methmeglobulin/
hypotension+flushing/tachcardia /headech كلهم بعملوا هيك

Question 17

nitrets contrainducation uses in

Answer 17

right vent infarction / hypertrophic cardiomyopathy/de5 inhepetors قلب خربان كيف بدك تستخدم اشي بقلل الperload

Question 18

renalozin se

Answer 18

Constipation, dizziness, headache, nausea.

Question 19

renalozine clincal uses

Answer 19

Refractory angina

Question 20

renalozine moa

Answer 20

Inhibits the late phase of inward sodium current thereby reducing diastolic wall tension and oxygen consumption

trets refractory angina
باخر خول الصوديوم قبل حصول الsystol بالتالي بتاخر الdiastol بالتالي بقل الwall tentsion للنو الخلايا مافيها صوديوم

Question 21

Digoxin moa

Answer 21

inhibit na/k pump – increase intra cell na leads to inhibits
ca/na pump leads to increas intra cell ca
that well increas contractlity

ب اختصار الصوديوم بضل جوا الكالسيوم بلحقه الضغطه بتزيد قوتها

Question 22

digoxin se

Answer 22

cholinergic effect بفتح الحنفيات vomtiong diaariha ausua

bluury yallow vissionبشتغل ع القلب
arrthmia and av blocks

hyperkalimia بوقف القناه تبعته
اذا عنده RF بتزيد احتمالية التسمم

Question 23

anti arrthmich drug type 1 moa + site of action(clincal use)

Answer 23

all of them works by Slow or block conduction / Effect most pronounced in IC>IA>IB due to relative binding strength CAB

a= كوين بروك تيزو = ((increase AP duration)),  effective (refractory period),  QT interva))) = بشتغل ع كل ال arrthmia

b= lidecoine+phenatouin +mixtoile= ((decreas AP duration. ))) affect ischemic = B الها بطنين كبار بشبهو الventriculs
vent uler arthmia(only) +post digoxin arrthmia + post mi arrthmia+not effect the QT INTERVAL

c= canned friise please= work by increases( refractory perioed) in AV node = works on atria only ((no chang in ap))

c= دويره صغيره بشتغل ع الatria مدور وصغير
باقي الcatogri بكل انواعها بتشتغل ع كل شي

Question 24

anti arthmia type 1 s/e

Answer 24

a= كوين بروك تيزو= الملكه لا اسنع لا ارى لا اتكلم =cinconism+ thrompocytopenia +qt prolongation +torsade de pointالقلب والدم بخربو لانو الملكه مش موجوده

b= deBBression of cns and cvs (phenotoin+lodicen+

c= proarrthmia+ its contraindication in ischmic heart diseas febtilitid + telibutid

Question 25

anti-arthmia type 2 (bb)moa site of action(clincal uses)

Answer 25

Decrease SA and AV nodal activity by  cAMP,  Ca 2+ currents + (((Suppress abnormal (afib+flutter)pacemakers ))) بتوقف الpacemaker(av+sa) تبعات القلب AV node particularly sensitive— PR interval. bb has asystmic effect through sympathtic system so its affect atrium and vent afib+ aflutter+prevent vent arthmia post mi

Question 26

antiarthmic type 2 se

Answer 26

metabolic of bb =dislipedima +hypoglycimia cvs (bradycardia+av block) propanlol excerpats vasoasm attacks rs effects excerbats (copd) etret with glucagone areopin and siline

Question 27

anti arrthmic type 3 (k+blocker)moa + clincal use

Answer 27

اختصار aids Amiodarone, Ibutilide, Dofetilide, Sotalol. (( increas AP duration)),  increass ERP=effict refractory period , increass QT interval. البوتاسيم تاثيره كبير ومهم بكل الخلايه ف بشتغل ع كل شي a fib +a flutter + vent tachy

Question 28

class 3 se

Answer 28

ibutilitde==toras de PPointفيه d و b كثير من اسمه saltalol=exsesive b blocer amidarone= فيه يود بالتركيبه تبعته بعمل hypo thyroied +hyper thyroied+ hepatotoxix+ pulmonary fibrosis AIDS

Question 29

type 4 ccb anti arrthmic clincal use and moa s/e

Answer 29

Decrease conduction velocity,  من الsa للav node== decreas  PR interval. and decreas sa node activity c=حرف صفير ومدور بشتغل ع الatria only s/e بعمل vasodilation =Constipation,flushing,edema, cardiovascular effects(HF, AV block, sinus node depression).

Question 30

statin moa

Answer 30

*hmg-coa reductase inhibiter = which is rate limiting step in cholisterol synthasis very effective in decreasing ldl decrease cholistrol synthasis decreas intrahepatic cholistrol ldl cycling ldl catabolism stat=بغير الatat تبعت الcholisterol ss ببطل موجود

Question 31

statin se

Answer 31

myopathy+ hepatotoxix ity

Question 32

bile acied rasins moa Cholestyramine, colesevelam, colestipol

Answer 32

increas conversion of cholistrol to bile that decreas intrahepatic cholistrole and increas ldl cycling ببداو ب chole

Question 33

bile acise rasins se

Answer 33

fat soluble vitmin malabsorbtion and gi irrtaion nasua

Question 34

Ezetimibe moa+ se

Answer 34

prevent fat absorbtion from gi cause increas in lft

Question 35

fibrates moa Fenofibrate, gemfibrozil

Answer 35

fibrats=بفرك اليفير بنطفه من الtg mainly affect triglycerids level through para-a activation: tri clearnce+ induce hdl synthasis

Question 36

fibrinat SE

Answer 36

myopathy+ increas gallstone formation بقلل الtri ف بزيد الcholistrol نسبيا بتحول لstone

Question 37

nicin moa

Answer 37

decreases lipolysis in fat tissue == decreas vldl .

Question 38

nicin SE

Answer 38

inhibit fat lypolysis causes flush face+hyperglycimia +hyperurcimia الجسم بعوض ال fat lysisب gluconegensis بدخل المريض ب hyperglycimia

Question 39

psck9 moa Alirocumab, evolocumab

Answer 39

antibody against ldl receptors degradation ضد الي بكسر مستقبلات الldl يؤدي لتقليل الlipid من ال blood streem بنتهي ب ocumab

Question 40

psck9 SE

Answer 40

ldl effect for sure causes an mylagia demnitia and diliruim اي اشي باثر ع الldl بعمل malygia

Question 41

fishoil moa

Answer 41

decreas free fatty acide travel in blood to liver decreasing enzyme making Tri g

Question 42

hf drugs?

Answer 42

ACE inhibitors, ARBs, angiotensin receptor–neprilysin inhibitors, β-blocker, and aldosterone receptor antagonists (spirenolactone)decreas mortality in HFrEF. Loop and thiazide diuretics are used mainly for symptomatic relief. Hydralazine with nitrate therapy improves both symptoms and mortality in select patients. ادوية ضغط + ادوية overload= ادوية بتقلل الموت المدرات=ادوية بتحسن الاعراض hydra+nitrat=بعملو كل شي

Question 43

drug reduce mortility in hf?

Answer 43

1-ACE inhibitors, 2-ARBs,3- angiotensin receptor–neprilysin inhibitors,4- β-blocker, 5-(spirenolactone) decreas mortality in HFrEF. 6- Hydralazine with nitrate therapy improves both symptoms and mortality in select patients كل شي الا +ccb +duritic + digoxin

Question 44

cardic drug-induced lupus erythematosus

Answer 44

New onset lupus symptoms Anti-nuclear antibodies (ANA) and anti-histone antibodies present in > 95% of cases Anti-dsDNA antibodies are rarely seen Exposure to implicated drugs Hydralazine Procainamide Isoniazid Minocycline Quinidine

Question 45

summry of action of anti arrthmia

Answer 45

1+3=condaction=increas ap duration 2+4= sa node deppression = increas pr interval 4= decreas condaction mainly type 1 = delay or bolck condaction from sa to av node a= كل شي vt+svt increas ap duration b= vt شكلها زي decreas ap duration الvent c=شكلها زي الatria no effect on ap svt+afib typ 2 bb = decreas sa + av activity and inhibits abnormal pacmaker =bb works on sympathatic resptor affect all the heart at once but mostly atria= vfib+flutter +vent arrthmia type 3= decreas condaction اجباري ياثر ع كامل القلبincreas AP duration = البوتاسيم قوي باثر ع كل شي=svt vt flutter type 4= decreas sa + ((mainly))decreas volicity of condation= increases pr interval + increases refractory period

Question 46

statin vs fibrenate main moa?

Answer 46

fibreats = work on triglyceride(شكل التخزين للناصح) statin= works on cholistrol levelشكل نقل الدهون hmg-reductas inhibition= inhbit rate limting step in fat synthasis

Question 47

لما تحكي انو هذا الدوا بشتغل ع atria او vent شو معناته؟

Answer 47

atria= svt afib a vent= mi + VT+drug induec like digoxin induce arrthmia+

Question 48

nitrts causes venous or artery dilation?

Answer 48

venouse but high does causes arterial dilation also

Question 49

anti-arrtmic drug prolonQT vs prolong ap?

Answer 49

prolong qt=الي فيهم بوتاسيم -k channle -claas 1 A changing ap=الي باثرو ع التوصيل اكيد بده يطول all class 1 الا اخر واحد all class 3 change pr=نفسهم الي باثرو على sa+av node -class 2 -class 4