Homeostasis
The dynamic mechanisms that detect and respond
to deviations in physiological variables from their
“set point” values by initiating effector responses that restore the variables to the
optimal physiological range.
Integrating Center pathway
Integrating center —>
effector —->
response —–>
NEGATIVE feedback
Stimulus —->
receptor —->
integrating center
Resting membrane potential
associated with leak channels
Equilibrium potential is…
calculated to be used as a tool to find out why other potentials work the way they do
K leak channel
driving force of resting potential
Equilibrium potential flux
net 0 when the concentration gradient and electrical gradient work tandem to make the net flux 0.
Equilibrium potential for each ion…
is independent of each other
Nernst equation
gives equilibrium at given concentrations for an ion
Goldman equation
why is resting potential closer to the Eq. Pot. of K+
The driving force of K+ is less than Na+ (V)
Na has a much higher driving force since it is farther from resting potential, however it has much more resistance
Amplitude of graded potentials
can vary and be different heights depending on stimulus. Duration of potential can be much longer with longer stimulus
graded v action potentials
graded can vary in amplitude and duration unlike action. Action cannot undergo summation.
Summation of graded potentials
multiple stimuli can combine the graded potentials to form a larger or smaller amplitude. They can cancel each other out. Summation can prevent the action potential from ever happening by preventing the threshold from being reached.
Stretch gates
when cell stretches, opens the gate which can trigger graded or action potential.
What does further increase in stimulus have on action potential
no effect, all or nothing
what does sustained stimulus have on action potential
can lead to a train of action potentials
when do action potentials occur
when a graded potential depolarizes the membrane past a threshold and proceeds with a very rapid high amplitude all or nothing behavior
what follows an action potential
Refractory period
when do graded potentials occur
when permeability is altered permitting Na+ or K+ to flow across membrane
As an Ion lke Na+ starts to flow into a cell, what happens to the driving force?
The driving force
what stops the Hodgkin Cycle
after inactivating, a ball and chain style structure closes the channel which stops Na+ influx.
During Action potential, the driving force for potassium first, _____ then _______
increases, decreases
decreases because the voltage decreases and gets closer to potassium level (distance gets closer - less driving force)