What is water movement faciitated by
channels, osmosis, filtration, and absorption
U/P =1
isoOsmotic
U/P > 1
Urine is hyperOsmotic ~ Urine releases solutes and solute content is decreased in plasma
Dehydration
U/P < 1
Urine is hypoOsmotic ~ Urine excretes water and solute content is released into plasma
Over hydration
3 reasons animals need water
respiratory water loss
fecal loss
urinary loss
what 3 things does the kidney produce
filtrate, ultrafiltrate, primary urine
what is the output from kidneys after processing
definitive Urine
3 functions of kidney
Filtration - rate is regulated
Absorption - filtered components can be re-absorbed
Secretion - Components that arent filtered are then added to filtration
What collects urine output?
Renal Pelvis, then drains to ureter which travels to bladder
Where are nephrons located?
Cortex and Medulla
What are nephrons composed of
1) Bowman’s capsule
2) Proximal Tubules
3) Loop of Henle
4) Distal Tubules
5) end at collecting duct
2 capillary networks of Nephrons
Glomerular capillaries - Bowman’s capsule
Pertibular Capillaries - Loop of Henle
Blood pathway in Kidney
1) Afferent Ateriole
2) Glomerular Capillaries (filtration step takes to bowman’s capsule)
3) Efferent Arteriole
4) Pertibular Capillaries (secretion can take to loop of Henle and absorption can take from Loop of henle to here)
5) Venules
Structure and Function of glomerular filtration
Nephrons enclose around the Glomerular capillaries.
Filtration is extremely fast here compared to other capillaries, this is due to highly porous nature.
Urine pathway in Kidneys
Glomerular Capillaries
Bowman’s Capsule
Proximal Tubule
Loop of Henle
Distal Tubule
Collecting Duct
Ureter
Bladder
What drives glomerular filtration rate?
Hydrostatic pressure drives blood into capsule, Osomotic pressure and hydrostatic pressure within the capsule can resist this movement
How can GFR be regulated?
contraction and dilation of arterioles to affect pressure
What is the dominant activity to modify filtrate
Reabsorption
What is the fate of filtered solutes?
majority are re absorbed
Glucose - 100%
Na+ and H2O nearly completely absorbed
Some are secreted into tubules like waste
how does length of loop of henle affect urine concentration
longer makes higher conc urine
Loop of henle function
Creates the osmotic gradient in the medulla that allows the kidney to make hyperosmotic (concentrated) urine when you need to save water.
when is ADH secreted by posterior pituitary
High plasma osmolarity or low plasma volume
what does ADH do
tell the kidney to absorb more water into the blood
Descending Limb in loop of henle function
Permeable to water
NOT permeable to solutes
Water leaves → filtrate becomes more concentrated as it moves downward
Think: “Water OUT.”