Unit 3: Pharm: Chapter 35

Question 1

Leuprolide

Answer 1

Drug that affects hypothalamic hormones
Used as antineoplastic agent for treatment of spefic cancers
Treatment of endometriosis and precocious putty that results from hypothalamic activity

Question 2

Leuprolide Actions

Answer 2

GnRH agonist that occupies pituitary GnRH receptors and desensitizes them; causes an initial increase and then profound decrease in LH and FSH levels.

Question 3

Leuprolide Adverse Effects

Answer 3

Dizziness, headache, pain, peripheral edema, myocardial infarction, nausea, vomiting, anorexia, constipation, urinary frequency, hematuria, hot flashes, increased sweating, malaise, fatigue, emotional lability, injection site pain, convulsions, testicular atrophy, decreased bone density, hyperglycemia.

Question 4

Desmopressin

Answer 4

Treatment of neurogenic diabetes insipidus, von Willebrand disease, hemophilia; treatment of nocturia due to nocturnal polyuria in adults.

Question 5

Desmopressin Actions

Answer 5

Has pressor and antidiuretic effects; increases levels of clotting factor VIII.

Question 6

Desmopressin Adverse Effects

Answer 6

eadache, dry mouth, facial flushing, nausea, fluid retention, slight increase in blood pressure, local reaction at injection site, water intoxication at high doses

Question 7

ADH

Answer 7

Vasopressin
Released from posterior pituitary in respsone to increased in plasma osmolarity or decrease in blood volume.
Antidiuretic activity in the kidneys
Vaspopressin blocker cause a loss of water through the urine and increases serum Na levels as water decreases

Question 8

Octreotide

Answer 8

Growth hormone antagonists
Treatment/maintenacne of acromegaly in adults who are not candidates for or cannot tolerate other therapy
Treatment for severe diarrhea/flusing with metastatic carcinoid tumors

Question 9

Hypothalamic Hormones

Answer 9

Factors to either stimulate or inhibit the release of hormones from the anterior pituitary.
Factors that stimulate the release of hormones are growth hormone–releasing hormone (GHRH), thyrotropin-releasing hormone (TRH), gonadotropin-releasing hormone (GnRH), corticotropin-releasing hormone (CRH), and prolactin-releasing hormone (PRH).
Factors that inhibit the release of hormones are somatostatin (growth hormone–inhibiting factor) and prolactin-inhibiting factor (PIF).