Aspirin

Question 1

Presentation of Aspirin

Answer 1

300mg tablet

Question 2

Pharmacology of Aspirin

Answer 2

Analgesic, antipyretic, anti-inflammatory & antiplatelet aggregation agent

Question 3

Pharmacology of Aspirin (actions)

Answer 3

Reduces platelet aggregation

Inhibits synthesis of prostaglandins

Question 4

Metabolism of Aspirin

Answer 4

Converted to Salicylate in the gut mucosa and liver, excreted mainly by the kidneys

Question 5

Aspirin Indications

Answer 5

To minimize platelet aggregation an thrombus formation in order to retard the progression of coronary artery thrombosis in acute coronary syndrome

Question 6

Aspirin Contraindications

Answer 6

• Bleeding Disorders
• Actively bleeding peptic ulcers
• Suspected dissecting aortic aneurysm
• Hypersensitivity to aspirin/salicylate
• Chest pain associated with psychostimulant OD if BP >160

Question 7

Aspirin Precautions

Answer 7

• Peptic ulcer
• Asthma
• Pt’s on anticoagulants e.g. Warfarin

Question 8

Route of Administration for Aspirin

Answer 8

Oral

Question 9

Side Effects of Aspirin

Answer 9

• Hypersensitivity reactions
• Increased bleeding time
• Nausea
• GI Bleeding
• Heartburn

Question 10

Aspirin Special Notes

Answer 10

Aspirin is contraindicated for use in acute febrile illness in children and adolescents.

Question 11

Effects of Aspirin

Answer 11

The anti-platelet effects of aspirin persist for the natural life of platelets

Duration: 8-10 days