Misoprostol

Question 1

Presentation of Misoprostol

Answer 1

200mcg tablet

Question 2

Pharmacology of Misoprostol

Answer 2

Synthetic prostaglandin

Question 3

Metabolism of Misoprostol

Answer 3

• Converted to active metabolite Misoprostol Acid in the blood
• Metabolised in the tissues and excreted by the kidneys

Question 4

Misoprostol Indications

Answer 4

Primary Post Partum Haemorrhage

Question 5

Misoprostol Contraindications

Answer 5

Allergy to prostaglandins

Ensure multiple prenancy excluded before drug administration

Question 6

Misoprostol Precautions

Answer 6

History of asthma

Question 7

Route of Administration of Misoprostol

Answer 7

Oral

Question 8

Side Effects of Misoprostol

Answer 8

• Abdominal pain and Diarrhoea
• Shivering
• Hyper-pyrexia

Question 9

Effects of Misoprostol

Answer 9

Oral
Onset: 8-10min
Duration: 2-3hrs

Question 10

Misoprostol Special Notes

Answer 10

Side effects more likely with >600mcg oral dose