Metoclopramide

Question 1

Presentation of Metoclopramide

Answer 1

10mg in 2ml ampule

Question 2

Pharmacology of Metoclopramide

Answer 2

• Antiemetic which accelerates gastric emptying and peristalsis
• Mild SHT3-receptor antagonist

Question 3

Metabolism of Metoclopramide

Answer 3

By the liver and excreted by the kidneys

Question 4

Metoclopramide Indications

Answer 4

Nausea/Vomiting associated with:

• Chest pain/discomfort of a cardiac nature
• Opiod administration for pain
• Previously diagnosed migrane
• Severe gastroenteritis
• Eye trauma
• Cytotoxic or radiotherpy
• Treatment or prophylaxis in awake spinal immobilised pts

Question 5

Metoclopramide Contraindications

Answer 5

• Suspected bowel obstruction or perforation
• Children
• GI haemorrhage

Question 6

Metoclopramide Precautions

Answer 6

• Undiagnosed abdo pain
• Adolescents (<20yrs)
• Administer slowly over one minute to minimise risk of extrapyramidial reactions

Question 7

Route of Administration of Metoclopramide

Answer 7

IV

IM

Question 8

Side Effects of Metoclopramide

Answer 8

• Muscle tremor
• Extrapyramidal reactions
• Drowsiness
• Dry mouth
• Lethergy

Question 9

Effects of Metoclopramide

Answer 9

IV
Onset: 1-3min
Duration: 10-30min

IM
Onset: 10-15min
Duration: 1-2hr