Midazolam

Question 1

Presentation of Midazolam

Answer 1

5mg in 1ml amp

15mg in 3ml amp

Question 2

Pharmacology of Midazolam

Answer 2

Short acting CNS depressant

Question 3

Pharmacology of Midazolam (actions)

Answer 3

• anxiolytic
• sedative
• anti-convulsant

Question 4

Metabolism of Midazolam

Answer 4

In the liver - excreted by the kidneys

Question 5

Midazolam Indications

Answer 5

• Seizures - continuous/recurrent
• Convulsions associated with Lignocaine toxicity
• Sedation in the aggitated pt
• Sedation in psychostimulant OD
• RSI
• Sedation to enable intubation
• Sedation to maintain intubation
• Sedation to enable synchronised cardioversion

Question 6

Midazolam Contraindications

Answer 6

Known hypersensitivity to benzodiazepines

Question 7

Midazolam Precautions

Answer 7

• Pts with myasthenia gravis
• Can cause severe respiratory depression in pts with COPD
• CNS depressant effects of benzo’s are enhanced in the presence of narcotics and other tranquillisers including alcohol
• Reduced doses may be required for the elderly, pts with chronic renal failure, CCF or shock

Question 8

Route of Administration of Midazolam

Answer 8

IM

IV

Question 9

Side Effects of Midazolam

Answer 9

• Loss of airway control
• Respiratory depression
• Hypotension
• Depressed level of consciousness

Question 10

Effects of Midazolam

Answer 10

IM
Onset: 3-5min
Peak: 15min
Duration: 30min

IV
Onset: 1-3min
Peak: 10min
Duration: 20min