Methoxyflurane

Question 1

Presentation of Methoxyflurane

Answer 1

3ml glass bottle with plastic seal

Question 2

Pharmacology of Methoxyflurane

Answer 2

Inhalational analgesic at low concentrations

Question 3

Metabolism of Methoxyflurane

Answer 3

Excreted mainly by the lungs

By the liver

Question 4

Methoxyflurane Indications

Answer 4

Pre-hospital pain relief

Question 5

Methoxyflurane Contraindications

Answer 5

• Pre-existing renal disease/renal impairment
• Concurrent use of tetracycline ABs
• Exceeding total dose of 6ml in a 24hr period

Question 6

Methoxyflurane Precautions

Answer 6

• Must be hand held by the pt

- Pre-eclampsia

Question 7

Route of Administration of Methoxyflurane

Answer 7

Self-administration under supervision using penthrox inhaler

Question 8

Side Effects of Methoxyflurane

Answer 8

• Drowsiness
• Decrease in BP and bradycardia (rare)
• Exceeding the max dose of 6ml in a 24hr period may lead to renal toxicity

Question 9

Effects of Methoxyflurane

Answer 9

• Analgesia commences after 8-10 breaths
• 3ml provides approximately 25min of analgesia
• Lasts for approximately 3-5min once discontinued