Morphine

Question 1

Presentation of Morphine

Answer 1

10mg in 1ml amp

Question 2

Pharmacology of Morphine

Answer 2

Narcotic analgesic

Question 3

Pharmacology of Morphine (actions)

Answer 3

CNS

• Depression (leading to analgesia)
• Respiratory depression
• Depression of cough reflex
• Dependance (addiction)
• Stimulation (changes in mood, euphoria or dysphoria, vomiting, pin-point pupils)

CV

• Vasodilation
• Decreases conduction velocity through the A.V. node

Question 4

Metabolism of Morphine

Answer 4

By the liver and excreted by the kidneys

Question 5

Morphine Indications

Answer 5

• Pain relief
• Acute LVF with SOB and full field crackles
• Sedation to maintain intubation
• Sedation to enable intubation
• RSI

Question 6

Morphine Contraindications

Answer 6

Known hyprsensitivity

Late second stage labour

Question 7

Morphine Precautions

Answer 7

• Current asthma
• Hypotension
• Elderly pts
• Respiratory depression
• Pts on MAOs
• Acute alcoholism
• Respiratory tract burns
• Known addiction to narcotics

Question 8

Route of Administration of Morphine

Answer 8

IM
IV
IV infusion

Question 9

Side Effects of Morphine

Answer 9

CNS

• Respiratory depression
• Euphoria
• Drowsiness
• Pin-point pupils
• Addiction
• Nausea, vomiting

CV

• Hypotension
• Bradycardia

Question 10

Effects of Morphine

Answer 10

IV
Onset: 2-5min
Peak: 10min
Duration: 1-2hrs

IM
Onset: 10-30min
Peak: 30-60min
Duration: 1-2hrs