The science of detecting and identifying the presence of drugs and poisons in tissues, organs, and body fluids.
Toxicology
specialized area of toxicology which deals specifically with animal, plant, and microbial toxins
Toxinology
are natural substances produced by living organisms.
Toxins
are synthetic substances from chemicals which are
considered toxicants.
Toxic substance
Importance of Toxicology
Toxicology is used to verify if a case being examined is poisoning or if there is a foul play in the crime scene, which may have caused the death of the victim.
Toxicology is an important tool in conducting criminal investigation that rely heavily on the analysis of toxins and toxic substances.
the condition wherein a toxic substance does not affect the body
the way it used to be (e.g., in the case of benzodiazepines, amphetamines, morphine, heroin, and methadone)
Tolerance
the opposite of tolerance, that is, small amounts can have fatal effects (e.g., in the case of aspirin, penicillin, cocaine, etc.)
Idiosyncrasy
aside from blood, lungs can also be checked for samples to
determine solvent abuse.
Lungs
many drugs tend to concentrate on
these areas.
Liver, Kidney, Brain, and Fat –
these are sources for bodies that are already decomposed.
Organs
these are excellent sources of samples to determine heavy metal poisoning, such as arsenic, antimony, or
thallium.
Hair and nail clippings
heavy metals often concentrate in the _____
Kidneys
can be a source of alcohol/drug sample
Vitreous humor
can be a source of samples of non-polar solvents, freon, or
chloroform
Brain
is a substance that when introduced into or absorbed by a living organism
causes death or injury.
Poison
is one that still poisons no matter how diluted it is.
True poison
is a substance that when introduced into or absorbed by a living organism
causes death or injury.
Poison
which by contact with it chemically produces local destruction of tissues.
Corrosive poison
one that increases suddenly in its intensity if action after gradual additions to it.
Cumulative poison
CLASSIFICATION OF POISONS
1. Based on Origin
a. Vegetable – poisons that comes from plants. (Ex. Poison Ivy)
b. Animal – poisons transferred through bites and stings of terrestrial
or marine animals. (Ex. Snake bites, sting from jellyfish and bees.)
c. Mineral – are strong acids and bases (Ex. HCL and NaOH)
d. Microbial – are poisons produced by microscopic organism. (Ex.
Bacteria in spoiled food and fungi found in expired bread)
e. Synthetic – are poisons chemically produced in the laboratory that
have useful importance to its purpose but become poisonous when
taken into the body. (Ex. Pesticides and overdose drugs)
Based on Chemical Properties
a. Metallic – are poisons that can be detected through isolation and
extraction using solvent extraction and flame test like test for arsenic
exhibits blue color on flame test.
5
b. Non-volatile Poisons – are poisons that can be analyzed through
extraction using solvents and confirmatory test with the use of
Fourier Transformed Infrared Spectrophotometer (FT-IR)
c. Volatile Poisons – are poisons that can be isolated through
distillation; its distillate can be analyzed using GC-MS
d. Anions – are poisons that can be detected through qualitative
methods of examination for the presence of anions. (Ex. Sulfates,
sulphides, chlorine, and alkalis)
e. Miscellaneous – other poisons. (Ex. Pesticides, herbicides, and
fertilizers)
one in which there is prompt and marked disturbance
of function or death within a shorter period of time and is due to:
1. Taking a strong poison
2. Excessive single dose
3. Several doses, small but frequentac
Acute poisoning
kind of poisoning in which there is gradual deterioration of functions of tissues and may or may not result in death. It may be produced by:
1. Taking several small doses at long intervals.
2. Taking only toxic doses of the drug.
Chronic poisoning