BBB

Question 1

explain mechanism of what occurs after nerve injury xox

Answer 1

• peripheral nerve is cut
• schwann cell wraps around distal part to form continuous line of cells (and make a tunnel)
• proximal end: nerve fibres form growth cones: grow back down inside the sheath
• in growth cone, have filopodia, (contain actin)
• filopodia adhere to the cell adhesion molecules on inner surface of schwann cells, contract and pull forward along tunnel
• schwann cells wrap myeline around nerve fibre
• nerve fibres regen at 1.5mm/ day