IgA Deficiency
M4:
- Person does not make enough IgA
- At higher risk for SLE
- Treatment: Monthly IgA shots
HIV/AIDs
M4:
- HIV invades the CD4 cells and takes over host DNA
- Antibody test/Antibody/antigen testing
- Inhibitor drugs
Systemic Lupus Erythematosus
M4:
- Auto inflammatory disease, T3 hypersensitivity, Antibodies directly damage tissues
- Butterfly rash, joint pain, heart problems
- Prevent organ damage, decrease drug toxicity–> NSAIDs, glucocortcoids, immune suppressants
Sarcoidosis
M4:
- Female, white, 50s, stressed
- Accumulation of T cells, macrophages and epithelioid granulomas (eye, skin, lungs, liver, lymph)
Sjogren’s Syndrome
M4:
- Female, over 40, family Hx of Autoimmune disease
- Autoimmune destruction of endocrine glands (salivary and lacrimal glands)
- Manage symptoms–> dry mouth, swollen glands
- Treat with artificial tears, saliva stimulants and immuneosuppresants
Rheumatoid Arthritis
M4:
- Ig mediated joint inflammation, RF reacts with with IGG to form immune complexes
- Get xrays of hands and feet to see deformities and do RF antibody testing
- Articular manifestations
- Joint pain after 30 minutes of rest
- Drugs: Disease modifying anti-rheumatic drugs, NSAIDs, glucocorsteriods