CLOPIDOGREL

Question 1

Drug class

Answer 1

anti-platelet

Question 2

How does it work? (2)

Answer 2

• binds irreversibly to adenosine bisphosphate receptors (ADP) (P2Y-12 subtype) - on the surface of platelets
• reduces formation of thrombus

Question 3

Indications (3)

Answer 3

1. heart

• ACS
• CVD
• AF
• coronary artery stents

2. brain
   - cereberovascular disease
3. peripheral artery disease

Question 4

Contra-indications (4)

Answer 4

1. severe active bleeding
2. elective surgery
3. renal impairment
4. hepatic impairment

Question 5

Side effects (3)

Answer 5

1. bleeding
2. GI upset

• dyspepsia
• abdo pain
• diarrhoea

RARE

3. thrombocytopenia

Question 6

Interactions (3)

Answer 6

1. cytochrome P450 inhibitors
   - metabolised by cytochrome P450
2. omeprazole
   - inhibits action
3. co-prescription with other anti-platelets and anti-coagulants
   - increases risk of bleeding

Question 7

Elimination (2)

Answer 7

1. renal

2. faecal