DOXAZOSIN

Question 1

Drug class

Answer 1

alpha blocker

Question 2

How does it work? (4)

Answer 2

1. blocks alpha-1-adrenoreceptor
2. these are found in smooth muscle e.g. blood vessels, urinary tract - bladder and neck of prostate
3. blocking alpha-1-reductase induces relaxation
4. this causes vasodilation and reduces resistance to bladder outflow

Question 3

Indications

Answer 3

1. BPH

2. resistant hypertension - last resort

Question 4

Contra-indications

Answer 4

1. postural hypotension

Question 5

Side effects (1 (3))

Answer 5

1. bp

• postural hypotension
• dizziness
• syncope

Question 6

Interractions

Answer 6

antihypertensive drugs combo

Question 7

Elimination (2)

Answer 7

1. faeces

2. urine