DIAZEPAM

Question 1

Drug class

Answer 1

benzodiazepines

Question 2

How does it work? (2)

Answer 2

1. they facilitate and enhance the binding of GABA to the GABA-A receptor
2. this has a widespread depressant effect on synaptic transmission as it prevents resistance to depolarisation

Question 3

What are depressant drugs?

Answer 3

they lower neurotransmission of neurotransmitter

Question 4

Indications (3)

Answer 4

1. head

• seizures
• anxiety
• status epilepticus
• sedation for procedures

2. alcohol withdrawal symptoms
3. insomnia

Question 5

Contra-indications (4)

Answer 5

1. age
   - elderly
2. resp
   - impairment
3. neuromuscular disease
4. liver failure
   - hepatic encpehalopathy

Question 6

Side effects (3)

Answer 6

1. head

• drowsiness
• sedation
• coma

2. dependence
3. withdrawal symptoms

Question 7

Interactions

Answer 7

1. cytochrome P450 inhibitors

e. g. amiodarone, dialiazem

Question 8

Elimination

Answer 8

urine