ERYTHROMYCIN

Question 1

Drug class

Answer 1

Macrolide

Question 2

How does it work? (3)

Answer 2

• inhibits bacterial protein synthesis
• hence is bacteriostatic
• consequently preventing bacteria from growing

Question 3

What types of bacteria does erythromycin target? (2)

Answer 3

broad spec

• gram positive
• some frame negative

Question 4

Indications (4)

Answer 4

1. resp - severe pneumonia
2. skin
3. soft tissue
4. GI - peptic ulcer - eradication of h.pylori

Question 5

Contra-indications (3)

Answer 5

• hypersensitivity to it
• hepatic impairment
• renal impairment

Question 6

Side effects (oral) (2)

Answer 6

1. GI effects - nausea, vomitting, abdo pain and diarrhoea

Question 7

Side effects IV (1)

Answer 7

1. thrombophlebitis

Question 8

General side effects (6)

Answer 8

1. irritant
2. allergy
3. antibiotic associated colitis
4. cholestatic jaundice
5. QT prolongation
6. Otoxicity

Question 9

Elimination

Answer 9

bile

Question 10

Interactions (2)

Answer 10

1. cytochrome p450 enzymes drugs

2. prolong QT interval drugs