RIVOROXABAN

Question 1

Drug class

Answer 1

novel anticoagulant

Question 2

How does it work? (3)

Answer 2

• binds to factor Xa
• prevents the formation of thrombin
• hence prevents the formation of blood clots

Question 3

Indications (3)

Answer 3

1. vessels

• dvt
• pe

2. surgery
3. heart
   - AF

Question 4

Contra-indications (2)

Answer 4

1. active bleeding

2. severe hypersensitivity reaction

Question 5

Side effects (there are a lot!) (8)

Answer 5

1. muscles and joints
   - back pain
2. GI

• black/red stools
• dark/red urine
• bowel or bladder dysfunction
• vomitting - blood or coffee ground material

3. gums
   - bleeding
4. head

• headache
• dizziness

5. pins and needles
6. leg weakness
7. prolonged bleeding from cuts
8. lungs
   - coughing up blood

Question 6

Interactions (4)

Answer 6

1. cytochrome P450 inhibitors
2. cytochrome P450 inducers
3. NSAIDs
4. Aspirin

Question 7

Elimination (2)

Answer 7

50: 50
1. hepatobiliary
2. renally