DICLOFENAC

Question 1

Drug class

Answer 1

NSAIDS

Question 2

how does it work? (2)

Answer 2

1. block COX enzymes

2. prevents the production of prostaglandins and distribution of them around the body

Question 3

Indications

Answer 3

1. pain

• periods
• inflammatory

Question 4

Contra-indications (4)

Answer 4

1. hypersensitivity
2. GI

• peptic ulcer
• bleeding

3. heart

• CVD
• heart failure

4. kidneys
   - severe renal impairment

Question 5

Side effects (5)

Answer 5

1. GI
   - toxicity
2. renal
   - impairment
3. heart
   - CVS events
4. hypersensitivity
5. fluid retention

Question 6

Interactions (9) a lot!!!!!

Answer 6

INCREASE GI ULCERATION

1. aspirin
2. corticosteroids

GI BLEEDING

3. anticoagulants
4. SSRIs

RENAL IMPAIRMENT

5. ACE inhibitors
6. diuretics

RISK OF BLEEDING

7. warfarin

REDUCED THERAPEUTIC EFFECTS

8. anti-hypertensives
9. diuretics

Question 7

Elimination (2)

Answer 7

1. urine mainly

2. some in bile