SIMVASTATIN

Question 1

Drug class

Answer 1

statin

Question 2

How does it work? (2)

Answer 2

1. reduces cholesterol levels (LDLs)

2. by inhibiting HGM coA reductase enzyme which is involved in cholesterol synthesis

Question 3

Indications (2)

Answer 3

1. CVD

2. hyperlipidaemia

Question 4

Contra-indications (3)

Answer 4

1. pregnancy and breast feeding
2. hepatic impairment
3. renal impairment

Question 5

Side effects (4)

Answer 5

1. head
   - headache
2. GI upset
3. Muscles

• rhabdomyolysis
• muscle aches

4. liver
   - rise in liver enzymes

Question 6

Interactions

Answer 6

cytochrome P450 inhibitors

e. g. amiodarone
- reduces effectiveness
- Grapefruit

Question 7

Elimination

Answer 7

1. renal