OMEPRAZOLE

Question 1

Drug class

Answer 1

proton pump inhibitor

Question 2

How does it work? (2)

Answer 2

1. reduces gastric acid secretion

2. by irreversibly inhibiting H+/K+ ATPase in gastric parietal cells

Question 3

What is the role of H+/K+ ATPase? (3)

Answer 3

• it is a proton pump
• responsible for secreting H+
• this generates gastric acid

Question 4

Indications (4)

Answer 4

• peptic ulcers
• dyspepsia
• GORD
• H.pylori

Question 5

Contra-indications (2)

Answer 5

• disguise symptoms of gastric cancer

- increased risk of fracture in elderly and osteoporosis patients (if prolonged courses used)

Question 6

Side-effects (4)

Answer 6

1. GI upset
2. headache
3. C.diff
4. hypomagnesaemia

Question 7

What can the severe hypomagesaemia lead to? (2)

Answer 7

• tetany

- ventricular arrhythmia

Question 8

Interactions (1)

Answer 8

1. reduces antiplatetlet effect of clopidogrel by decreasing it’s activation by cytochrome P450 enzyme

Question 9

Elimination (2)

Answer 9

• 80% renal

- 20% faecal