DOXYCYCLINE

Question 1

Drug class

Answer 1

tetracycline

Question 2

How does it work?

Answer 2

• inhibits bacterial protein synthesis

- bactriostatic

Question 3

Is doxycycline broad or narrow spectrum?

Answer 3

broad

Question 4

Indications (4)

Answer 4

1. skin
   - acne vulgaris
2. Lungs

• LRTI
• infective exacerbations of COPD

3. Pelvis
   - chlamydia
4. Infectious

• typhoid
• anthrax
• lyme disease

Question 5

Contra-indications (3)

Answer 5

1. pregnancy and breast feeding
2. kids under 12 years old
3. renal impairment

Question 6

Side effects (4)

Answer 6

1. GI

• diarrhoea
• vomitting
• nausea

2. Hypersensitivity
3. Oesophageal

• irritation
• ulceration
• dysphagia

4. Head

• intra-cranial hypertension
• headache
• visual disturbance
• photosensitivity
• hypoplasia of tooth enamel
• discolouration

Question 7

Interactions (3)

Answer 7

1. Divalent cations
   - binds to them
2. calcium, antacids and iron

• will prevent antibiotic absorption
• not to be given with in 2 hours of them

3. warfarin
   - enhance anti-coagulant effects

Question 8

Elimination (2)

Answer 8

1. bile

2. urine