TIOTROPIUM

Question 1

Drug class

Answer 1

anticholinergic

Question 2

How does it work? (2)

Answer 2

• bind to muscarinic receptor

- they act as a competitive inhibitor of acetylcholine

Question 3

What does stimulation of the muscarinic receptors bring about?

Answer 3

• wide range of parasympathetic/ ‘rest and digest’ effects

Question 4

What does blocking the muscarinic receptors bring about? (6)

Answer 4

• increase heart rate
• increased heart conduction
• reduced smooth muscle tone in resp tract
• reduced secretions from glands in reap and GI tracts

eyes

• cause relaxation of the pupillary constrictor, cilary muscles
• cause pupillary dilation
• prevent accommodation

Question 5

Indications (2)

Answer 5

• COPD

- Asthma

Question 6

Contra-indications (2)

Answer 6

• Angle closure glaucoma

- dangerous rise in intro-occular pressure

Question 7

Side effects

Answer 7

dry mouth

Question 8

Interactions

Answer 8

none

Question 9

Elimination (2)

Answer 9

• IV –> urine

- inhalation –> faeces