RANITIDINE

Question 1

drug class

Answer 1

H2 receptor antagonist

Question 2

how does it work? (6)

Answer 2

• reduces gastric acid secretion
• the proton pump is regulated by histamine
• histamine is released by local paracrine cells
• histamine then binds to H2 receptors on the gastric parietal cell
• this activates the proton pump
• Ranitdine binds to H2 receptor preventing this action

Question 3

How does the proton pump work and what does it do? (3)

Answer 3

• it produces gastric acid
• by secreting H+ into the stomach lumen
• this is in exchange for drawing K+ into the cell

Question 4

Which messenger system activates the proton pump?

Answer 4

second messenger sysetm

Question 5

Do H2 receptor antagonists completely suppress gastric acid production?

Answer 5

no

Question 6

Do PPIs completely suppress the gastric acid production?

Answer 6

yes

Question 7

Indications (3)

Answer 7

• peptic ulcer disease
• GORD
• dyspepsia

Question 8

Contra-indications (2)

Answer 8

• dose should be reduced in renal patients

- disguise symptoms of gastric cancer

Question 9

Side effects (3)

Answer 9

• bowel disturbance
• headache
• dizziness

Question 10

Interactions

Answer 10

none

Question 11

Elimination

Answer 11

kidneys