WARFARIN

Question 1

Drug class

Answer 1

oral anticoagulant

Question 2

How does it work? (2)

Answer 2

1. inihibits hepatic production of vit K dependent coagulation factors and co-factors
2. it does this by inhibiting bit K epoxide reductase enzyme

Question 3

Indications (2)

Answer 3

1. vessels

• dvt
• pe

2. heart

• af
• heart valve replacement

Question 4

Contra-indications (3)

Answer 4

1. risk of haemorrhage
2. liver disease
3. pregnancy

Question 5

Interactions (3)

Answer 5

1. cytochrome P450 inhibitors
   - fluclonazole
2. cytochrome inducers
   - phenytoin
3. some antibiotics

Question 6

Side effects

Answer 6

bleeding

Question 7

Elimination

Answer 7

urine