FLUDROCORTISONE

Question 1

Drug class

Answer 1

mineralocorticoids

Question 2

What does it do? (3)

Answer 2

1. replaces aldosterone in adrenal insufficiency
   - Addison’s
2. increases sodium levels
3. increased blood vol

Question 3

How does it work? (3)

Answer 3

1. binds to mineralocorticoid receptor (aldosterone receptor)
2. this causes an increase in ion and water transport
3. this raises extracellular fluid and bp

Question 4

Indications

Answer 4

Addison’s disease

Question 5

Contra-indications (8)

Answer 5

1. allergic
2. systemic fungal infection
3. live virus vaccination e.g. smallpox
4. pregnancy
5. underactive thyroid
6. kidney and liver problems
7. recent TB
8. eye infection

• measles
• chicken pox
• herpes

Question 6

Side effects (5)

Answer 6

1. GI

• upset
• vomitting
• indigestion
• increased appetite

2. head

• dizzy
• lightheadedness
• headache

3. mood
   - nervousness
4. sleep difficulty
5. increased sweating

Question 7

Interactions (4) - 3am

Answer 7

1. anabolic steroids
2. methotrexate
3. anticoagulants
4. amphoetericin B

Question 8

Elimination (2)

Answer 8

1. urine mainly

2. faeces and bile