LAMOTRIGINE

Question 1

Drug class

Answer 1

anti-convulsant

Question 2

How does it work? (3)

Answer 2

1. enhances GABA
   - this is an inhibitory neurotransmitter
2. reduces transmission of pain
3. inhibits voltage gated sodium channels

Question 3

Indications (2)

Answer 3

1. epilepsy

2. bipolar

Question 4

Contra-indications (3)

Answer 4

1. hormones
2. pregnancy
3. breast-feeding

Question 5

Side effects (4)

Answer 5

1. life threatening skin reactions
   - Steven-Johnson’s syndrome
2. Rash, fever and fatigue
3. loss of balance and vision
4. sleep

Question 6

Interactions

Answer 6

1. drugs metabolised by cytochrome P450 enzymes

Question 7

Elimination

Answer 7

urine