Microbiology flipped classroom 2

Question 1

What is the general propertis of spirpchetes

Answer 1

• Thin walled
  -Spiral shaped rods

Question 2

Name 2 types of spirochetes

Answer 2

-Treponema+ leptospira
-Borrelia

Question 3

What disease does Treponema Pallidum caused

Answer 3

• Syphilis

Question 4

What are important properties of Treponema pallidumx3

Answer 4

• Cannot be grown
  -Extremely fastidous
  -Motile

Question 5

How is Treponema pallidum transmitted
+ reservoir

Answer 5

• Humans only
  -Sexual contact,
  transplancental

Question 6

Explain what happens in primary syphilis
- Symptoms

Answer 6

• Chancre ( firm, painless)

Question 6

Explain the pathogenesis of Treponemia
-WHat does it not produce
-What does it invade + cause

Answer 6

-Dosent produce importnat toxins or enzymes
- Invades endothelium of small blood vessels

Causes:
- Endarteritis
-Perivascular inflammatory infiltrates

Question 7

Name the 5 clinical stages of syphilis

Answer 7

• Primary syphills
  -Secondary
  -Latent
  -Tertiary
  -congenital

Question 8

Explain secondary syphilis
- What is it due to
+ symptoms

Answer 8

• Due to hematogenous spread
• Maculopapular rash- in palms and soles ( non itchy)
  -Condylomata lata - in genital area

Question 9

Name the 3 main symotoms that occur in tertiary syphillis

Answer 9

• Gummatous syphilis
  -Cardiovascular syphilis
  -Neurosyphilis

Question 10

How is congenital syphils transmitted

Answer 10

• In utero

Question 11

What are clinical features of congenital syphilis in Utero + in early congenital syphilis

Answer 11

-Miscarriage
-Stillbirth
-Hydrops fetalis

• Snuffles
  -jaundice

Question 12

Name 2 non specific test for syphyillis

Answer 12

• VDRL
  -RPR

Question 13

Name 2 specific tets for syphili

Answer 13

-FTA-ABS
-MHA-TP

Question 14

Name the 2 parts in Latent syphilis + describe them

Answer 14

• Early Latent
• Secondary symptoms may occur
  -Late Latent
• Asymptomatic
  not infectious

Question 15

What is Syphyillis treated with

Answer 15

Penicillin

Question 16

Give a characteritics of Borrelia

Answer 16

• Can grow

Question 17

Name 3 important species of borrelia + the diseases they cause

Answer 17

Borellia burgdoferi - Lyme diseasw
-Borrelia recurrentis - louse borne relapsing fever

-borrelia hermsii- Tick borne relapsing fever

Question 18

Explain the disease caused by Borrelia
- What is it transmited by
-Reservoir
-

Answer 18

• Tick bite
• Small mamals

Question 19

Name the 3 clinical stages of lyme disease

Answer 19

• Stage 1 - Early localized
  stage 2 - Early disseminated
  Stage 3 - Late disseminated

Question 20

Explain the clinical course of Lyme disease stage 1 - early localised
-When does it occur
-What is the hallmark symptoms o

Answer 20

• Dyas - weeks after bite
• Erythema migrans
  + expaninding bulls eye rash

Question 21

Explain the second clinical course of early disseminated
- Explain the timing
-X3 symptoms

Answer 21

• Musculoskeletal:
• Migratoty arthralgia

Early neuroborrseliosis
Cranial nerve palsy

Cardiac
- Lyme carditis

Question 22

Explain the 3rd clinical cours of lyme disease
- Late disseminated
- When does it occur- timing
- Name the 2 conditions present

Answer 22

• Chronic lyme arthritis
  -Late neuroborreliosis

Question 23

How is borrelia- lyme disease treated

Answer 23

- Doxycyline

Question 24

Explain B. Recurrentis+ B.hermsii - Reservoir -symtoms

Answer 24

Recurrentis- Humans ony Hermsii- Rodents -Fevre, chills, headache

Question 25

Explain characteristics of leptospira -structure

Answer 25

- Spirochetes with hooked ends - question mark shape

Question 26

Explain lepospira: -The infected animals -Contamination of what -How are humans affetced

Answer 26

- Rats, pets - Contaminated water and soil - Human infection via : -contaminated water/food

Question 27

Name the 2 phases of the disease caused by leptospira

Answer 27

-Phase 1 - Septicemic phase Phase 2 - Immune phase

Question 28

Explain the septicemic phase of leptospirosos -symptoms

Answer 28

= Fever, chills, headache, vomitting diarrhea

Question 29

Explaon the phase 2 - immune phase of leptospirosis - symptoms

Answer 29

Jaundice

Question 30

How is leptospirosis trated

Answer 30

- Penicillin