atherosclerosis

Question 1

1 local and 3 systemic consequences of athero

Answer 1

local - aneurism

system - ischemic heart disease, cerebral vascular disease, peripheral vascular

Question 2

what is pre-athero sign

Answer 2

fatty streaks

Question 3

what is seen next

Answer 3

lesions that begin to coalesce

Question 4

what can happen next

Answer 4

thrombus, erosion

Question 5

what is cholest. crystal

Answer 5

embolism that breaks off and can travel in vessel

Question 6

what happens in unstable athero

Answer 6

1. thinned epithelium
2. fibrous cap rupture
3. blood gets in and makes thrombus

Question 7

what happens in adaptation stage

Answer 7

1. small break in endothelium
2. macrophages enter
3. macros eat lipis and become lipid laden (foam cells)
4. SMC enter and proliferate in the intima

Question 8

7 steps in clinical stage

Answer 8

1. mural thrombus
2. embolization
3. plaque hemorrage
4. plaque rupture
5. aneurysm
6. stenosis
7. thrombisis

Question 9

3 active areas of athero research

Answer 9

1. inflammation in the plaque
2. cause of plaque rupture
3. inducing plaque regression