chronic inflammation

Question 1

3 requirements for resolution of acute inflammation

Answer 1

1. short lived
2. very limited damage
3. capacity for cell regeneration

Question 2

3 possible outcomes of acute inflammation

Answer 2

1. resolution
2. healing - fibrosis - scarring
3. chronic inflammation

Question 3

def. chronic inflammation

Answer 3

inflamm. of prolonged duration in which inflammation, tissue injury, and attempt to repair co-exist

Question 4

2 things that chronic inflammation is trying to resolve

Answer 4

1. continuous injury

2. dysregulated immune repsonse

Question 5

3 cardinal features of chronic inflammation

Answer 5

1. a component of non-neutrophilic inflammation (macro, lymphocytes, plasma cells)
2. architectural destruction
3. tissue fibrosis

Question 6

what are macrophage stages

Answer 6

1. marrow
2. into blood -monocyte
3. into tissue as macrophage or activated macrophage

Question 7

what happens to macrophages in tissues

Answer 7

either goes to towards healing/repair pathway or proinflmmatory pathway

Question 8

what happens with persistent injury

Answer 8

INF-Gamma causes granulomatous inflammation

Question 9

def. granuloma

Answer 9

collection of activated macrophages surrounded by chornic inflammation

Question 10

def. granulomatous inflammation

Answer 10

distinctive pattern of chronic inflammation resulting from an antigen that is difficult to eradicate

Question 11

2 types of granuloma

Answer 11

1. immune granuloma - poorly degradable antigen or paticle causes cell mediated inflammation
2. foreign body - something too large to phag.

Question 12

2 types of perisisent injurious stim.

Answer 12

1. persistent infeciton - myobacteium - abundant INF-G

2. insoluble inert substance

Question 13

3 types of immune related chronic inflammation

Answer 13

1. autoimmune
2. immune dysregulation
3. hypersensitivity reactions

Question 14

what is autoimmune reaction

Answer 14

persistent and eccessive stimulation due to self-antigen

Question 15

what is immune dysregulation

Answer 15

(IBD) - unregulated response to microbes