RBCs

Question 1

foundation of Hb

Answer 1

heme+globin

Question 2

function of heme

Answer 2

carries O2 and CO2

Question 3

function of globin

Answer 3

structure and protection of heme

Question 4

different types of Hb and when

Answer 4

HbA - adult
HBF - fetal
HbE - embryo

Question 5

structure of HbA

Answer 5

• 4 subunits=4 O2

- a2B2

Question 6

2 states of Hb and affinity

Answer 6

relaxed - high O2 affinity, low CO2

tense - low O2 affinity, high Co2

Question 7

what changes affinity

Answer 7

15 degree rotations

Question 8

what does myoglobin supply

Answer 8

muscle

Question 9

diff between Mb and Hb

Answer 9

Mb is monomer - no cooperativity

Question 10

why do we need Mb

Answer 10

takes O2 from Hb at low sat points and brings to muscles

Question 11

what does acid do

Answer 11

• moves Hb affiinty curve to right

- Hb less affinity at low O2 sat. levels

Question 12

what shifts curve to R (3)

Answer 12

1. acid
2. diphosophglycerate
3. high temp

Question 13

what shifts curve to L (4)

Answer 13

1. high pH
2. low temp
3. high CO
4. fetal Hb

Question 14

what is count of Hb

Answer 14

HgB - amount of protein in blood

Question 15

formula for hematocrit

Answer 15

Hgb x 3 - percent og blood that is RBC

Question 16

2 important factors for O2 capacity of person

Answer 16

1. hematocrit

2. volume of blood

Question 17

production change times of Hb types

Answer 17

E to y(fetal) - -6 months

y to B(adult - +6 months

Question 18

define dyshemoglobinemias

Answer 18

Fe is oxydized to 3+

Question 19

consequences of dyshemoglobinemias

Answer 19

can’t carry O2

Question 20

treatment of dyshemoglobinemias

Answer 20

methylene blue - oxydizes